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A brain reward circuit inhibited by next-generation weight-loss drugs in mice.

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Title: A brain reward circuit inhibited by next-generation weight-loss drugs in mice.
Authors: Godschall EN; Department of Biology, University of Virginia, Charlottesville, VA, USA., Gungul TB; Department of Biology, University of Virginia, Charlottesville, VA, USA., Sajonia IR; Department of Biology, University of Virginia, Charlottesville, VA, USA., Buyukaksakal AK; Department of Biology, University of Virginia, Charlottesville, VA, USA., Li O; Department of Biology, University of Virginia, Charlottesville, VA, USA., Ogilvie S; Department of Biology, University of Virginia, Charlottesville, VA, USA., Keeler AB; Department of Biology, University of Virginia, Charlottesville, VA, USA., Tian G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Shi Y; Department of Biology, University of Virginia, Charlottesville, VA, USA., Koita O; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Department of Psychiatry, University of Washington, Seattle, WA, USA., Guo CX; Department of Biology, University of Virginia, Charlottesville, VA, USA., Deutsch TCJ; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA., Steacy EJ; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA., Crook M; Department of Biology, University of Virginia, Charlottesville, VA, USA., Zhang Y; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA., Conley NJ; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA., Memi G; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Department of Physiology, School of Medicine, Adiyaman University, Adiyaman, Turkey., Webster AN; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA., Yipkin Calhan O; Department of Biology, University of Virginia, Charlottesville, VA, USA., Liu W; Department of Biology, University of Virginia, Charlottesville, VA, USA., Akkoub A; Department of Biology, University of Virginia, Charlottesville, VA, USA., Malik K; Department of Biology, University of Virginia, Charlottesville, VA, USA., West KI; Department of Biology, University of Virginia, Charlottesville, VA, USA., Michel-Le S; Department of Biology, University of Virginia, Charlottesville, VA, USA., Karthikeyan A; Department of Biology, University of Virginia, Charlottesville, VA, USA., van Gerven G; Department of Biology, University of Virginia, Charlottesville, VA, USA., Dell'Aglio OA; Department of Biology, University of Virginia, Charlottesville, VA, USA., Beier KT; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Zweifel LS; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Department of Psychiatry, University of Washington, Seattle, WA, USA., Patel MK; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA., Campbell JN; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA., Deppmann CD; Department of Biology, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Department of Cell Biology, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu., Güler AD; Department of Biology, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.
Source: Nature [Nature] 2026 Jun; Vol. 654 (8120), pp. 1055-1064. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: A brain reward circuit inhibited by next-generation weight-loss drugs in mice.
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  Data: <searchLink fieldCode="AU" term="%22Godschall+EN%22">Godschall EN</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Gungul+TB%22">Gungul TB</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Sajonia+IR%22">Sajonia IR</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Buyukaksakal+AK%22">Buyukaksakal AK</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Li+O%22">Li O</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Ogilvie+S%22">Ogilvie S</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Keeler+AB%22">Keeler AB</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Tian+G%22">Tian G</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Koita+O%22">Koita O</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Department of Psychiatry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Guo+CX%22">Guo CX</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Deutsch+TCJ%22">Deutsch TCJ</searchLink>; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Edward Via College of Osteopathic Medicine, Blacksburg, VA, USA.<br /><searchLink fieldCode="AU" term="%22Steacy+EJ%22">Steacy EJ</searchLink>; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Crook+M%22">Crook M</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Conley+NJ%22">Conley NJ</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Memi+G%22">Memi G</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Department of Physiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.<br /><searchLink fieldCode="AU" term="%22Webster+AN%22">Webster AN</searchLink>; 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Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22van+Gerven+G%22">van Gerven G</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Dell'Aglio+OA%22">Dell'Aglio OA</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Beier+KT%22">Beier KT</searchLink>; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Zweifel+LS%22">Zweifel LS</searchLink>; Department of Pharmacology, University of Washington, Seattle, WA, USA.; Department of Psychiatry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+MK%22">Patel MK</searchLink>; Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+JN%22">Campbell JN</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22Deppmann+CD%22">Deppmann CD</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Department of Cell Biology, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. deppmann@virginia.edu.<br /><searchLink fieldCode="AU" term="%22Güler+AD%22">Güler AD</searchLink>; Department of Biology, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.; Neuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA. aguler@virginia.edu.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Jun; Vol. 654 (8120), pp. 1055-1064. <i>Date of Electronic Publication: </i>2026 May 06.
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