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Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis.

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Title: Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis.
Authors: Riggio AI; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Sweeney K; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Shaw R; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Lawlor A; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Khan A; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Ferrari N; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Anand J; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Galbraith LC; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Gilroy K; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Bull C; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Young AL; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Athineos D; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Hall H; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Ghaffar F; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Hughes M; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Mitchell CA; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Mitchell L; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Nixon C; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Adams PD; Sanford Burnham Prebys Medical Discovery Institute, North Torrey Pines Road, La Jolla, CA, USA., Roberts EW; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Miller CJ; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK., Dunne PD; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Campbell KJ; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK., Cameron ER; School of Biodiversity One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK. Ewan.Cameron@glasgow.ac.uk., Blyth K; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK. Karen.Blyth@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK. Karen.Blyth@glasgow.ac.uk.
Source: British journal of cancer [Br J Cancer] 2026 May 07. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: Runx1 and Runx2 act in concert to suppress Wnt/β-catenin-driven mammary tumourigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Riggio+AI%22">Riggio AI</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+K%22">Sweeney K</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+R%22">Shaw R</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Lawlor+A%22">Lawlor A</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Khan+A%22">Khan A</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ferrari+N%22">Ferrari N</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Anand+J%22">Anand J</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Galbraith+LC%22">Galbraith LC</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Gilroy+K%22">Gilroy K</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Bull+C%22">Bull C</searchLink>; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Young+AL%22">Young AL</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Athineos+D%22">Athineos D</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hall+H%22">Hall H</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Ghaffar+F%22">Ghaffar F</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Hughes+M%22">Hughes M</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+CA%22">Mitchell CA</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+L%22">Mitchell L</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Nixon+C%22">Nixon C</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Adams+PD%22">Adams PD</searchLink>; Sanford Burnham Prebys Medical Discovery Institute, North Torrey Pines Road, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Roberts+EW%22">Roberts EW</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Miller+CJ%22">Miller CJ</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Dunne+PD%22">Dunne PD</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.; The Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.<br /><searchLink fieldCode="AU" term="%22Campbell+KJ%22">Campbell KJ</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Cameron+ER%22">Cameron ER</searchLink>; School of Biodiversity One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK. Ewan.Cameron@glasgow.ac.uk.<br /><searchLink fieldCode="AU" term="%22Blyth+K%22">Blyth K</searchLink>; Cancer Research UK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, UK. Karen.Blyth@glasgow.ac.uk.; School of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, UK. Karen.Blyth@glasgow.ac.uk.
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