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Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.

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Title: Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.
Authors: Jorda A; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Gelbenegger G; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Shapiro NI; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States., Douglas IS; Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla, NY, United States., Whitman C; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Chen Z; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Hippensteel JA; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States., Kamphuis LA; VA Center for Clinical Management Research, Ann Arbor, VA, Ann Arbor, MI, United States., Flick RJ; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States., Harhay MO; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States., Caldwell E; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Washington, Seattle, WA, United States., Zeitlinger M; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Jilma B; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria., Iwashyna TJ; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States., Hough CL; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University School of Medicine, Portland, OR, United States.; The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network, Boston, MA, United States., Auriemma CL; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1510-1521.
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Thoracic Society Country of Publication: England NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Effects of an early restrictive versus liberal fluid strategy on long-term patient-centered outcomes in sepsis-induced hypotension: an open-label, randomized controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Jorda+A%22">Jorda A</searchLink>; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gelbenegger+G%22">Gelbenegger G</searchLink>; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Shapiro+NI%22">Shapiro NI</searchLink>; Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Douglas+IS%22">Douglas IS</searchLink>; Department of Medicine, New York Medical College, Westchester Medical Center, Valhalla, NY, United States.<br /><searchLink fieldCode="AU" term="%22Whitman+C%22">Whitman C</searchLink>; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Hippensteel+JA%22">Hippensteel JA</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.<br /><searchLink fieldCode="AU" term="%22Kamphuis+LA%22">Kamphuis LA</searchLink>; VA Center for Clinical Management Research, Ann Arbor, VA, Ann Arbor, MI, United States.<br /><searchLink fieldCode="AU" term="%22Flick+RJ%22">Flick RJ</searchLink>; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Harhay+MO%22">Harhay MO</searchLink>; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22Caldwell+E%22">Caldwell E</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Washington, Seattle, WA, United States.<br /><searchLink fieldCode="AU" term="%22Zeitlinger+M%22">Zeitlinger M</searchLink>; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jilma+B%22">Jilma B</searchLink>; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Iwashyna+TJ%22">Iwashyna TJ</searchLink>; Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States.; Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.<br /><searchLink fieldCode="AU" term="%22Hough+CL%22">Hough CL</searchLink>; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health and Science University School of Medicine, Portland, OR, United States.; The National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Network, Boston, MA, United States.<br /><searchLink fieldCode="AU" term="%22Auriemma+CL%22">Auriemma CL</searchLink>; Palliative and Advanced Illness Research (PAIR) Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
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  Data: <searchLink fieldCode="JN" term="%229421642%22">American journal of respiratory and critical care medicine</searchLink> [Am J Respir Crit Care Med] 2026 Jul 01; Vol. 212 (7), pp. 1510-1521.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Thoracic+Society%22">American Thoracic Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421642 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1535-4970 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221073449X%22">1073449X </searchLink><i>NLM ISO Abbreviation: </i>Am J Respir Crit Care Med <i>Subsets: </i>MEDLINE
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