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Estrogen-mediated NF-κB blockade enables breast cancer sensitivity to oncolytic VSV virotherapy.

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Title: Estrogen-mediated NF-κB blockade enables breast cancer sensitivity to oncolytic VSV virotherapy.
Authors: Viens M; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Geoffroy K; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Meuriot E; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Buccilli A; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Mullins-Dansereau V; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Myre ML; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Paradisis S; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Bardoul A; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Kalin EM; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Saraiva BA; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Valencia J; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Leclerc Desaulniers K; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada., Hoang HD; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Hassan S; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada., Bell JC; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada., Vanderhyden B; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Alain T; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Roy DG; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada., Cook DP; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada., Bourgeois-Daigneault MC; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada. Electronic address: marie-claude.bourgeois-daigneault@umontreal.ca.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 May 05. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Estrogen-mediated NF-κB blockade enables breast cancer sensitivity to oncolytic VSV virotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Viens+M%22">Viens M</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Geoffroy+K%22">Geoffroy K</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Meuriot+E%22">Meuriot E</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Buccilli+A%22">Buccilli A</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Mullins-Dansereau+V%22">Mullins-Dansereau V</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Myre+ML%22">Myre ML</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Paradisis+S%22">Paradisis S</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Bardoul+A%22">Bardoul A</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Kalin+EM%22">Kalin EM</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Saraiva+BA%22">Saraiva BA</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Valencia+J%22">Valencia J</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Leclerc+Desaulniers+K%22">Leclerc Desaulniers K</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Hoang+HD%22">Hoang HD</searchLink>; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Hassan+S%22">Hassan S</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Bell+JC%22">Bell JC</searchLink>; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada.<br /><searchLink fieldCode="AU" term="%22Vanderhyden+B%22">Vanderhyden B</searchLink>; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Alain+T%22">Alain T</searchLink>; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Roy+DG%22">Roy DG</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+DP%22">Cook DP</searchLink>; Cancer Research Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.<br /><searchLink fieldCode="AU" term="%22Bourgeois-Daigneault+MC%22">Bourgeois-Daigneault MC</searchLink>; Cancer Axis and Institut du Cancer de Montréal, Centre Hospitalier de l'Université de Montréal (CHUM) Research Center, Montreal, QC H2X 0A9, Canada; Immunopathology Axis, CHUM Research Center, Montreal, QC H2X 0A9, Canada; Department of Microbiology, Infectious Diseases, and Immunology, University of Montreal, Montreal, QC H3C 3J7, Canada. Electronic address: marie-claude.bourgeois-daigneault@umontreal.ca.
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