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Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.

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Title: Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.
Authors: Nguyen APT; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA., Moser R; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland., Bryant N; Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA., Cunningham LA; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA., Worden EJ; Departments of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, USA., Moore DJ; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Apr 27. Date of Electronic Publication: 2026 Apr 27.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+APT%22">Nguyen APT</searchLink>; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.; Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.<br /><searchLink fieldCode="AU" term="%22Moser+R%22">Moser R</searchLink>; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bryant+N%22">Bryant N</searchLink>; Center for Neurodegeneration and Neurotherapeutics, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cunningham+LA%22">Cunningham LA</searchLink>; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.<br /><searchLink fieldCode="AU" term="%22Worden+EJ%22">Worden EJ</searchLink>; Departments of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, USA.<br /><searchLink fieldCode="AU" term="%22Moore+DJ%22">Moore DJ</searchLink>; Departments of Neurodegenerative Science, Van Andel Institute, Grand Rapids, Michigan 49503, USA.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Apr 27. <i>Date of Electronic Publication: </i>2026 Apr 27.
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  Data: Journal Article; Preprint
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42094571
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        Value: 10.64898/2026.04.23.720426
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      – Code: eng
        Text: English
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      – TitleFull: Parkinson's disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integrity.
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              Text: 2026 Apr 27
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