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The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications.

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Title: The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications.
Authors: Tsepilov YA; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Suveges D; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Considine D; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Szyszkowski S; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Ge XJ; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Santiago IL; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Rusina P; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Alegbe T; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Ho VW; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Tsukanov K; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Roldán-Romero JM; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Smit IA; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Cornu H; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Harris L; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Alasoo K; University of Tartu, Ülikooli 18, 50090 Tartu, Estonia., Predeus A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., Lessard S; Target, Disease & Systems Biology, Sanofi, 350 Water Street, Cambridge, MA 02141, USA., Chatelain C; Target, Disease & Systems Biology, Sanofi, 350 Water Street, Cambridge, MA 02141, USA., Khader S; Target, Disease & Systems Biology, Sanofi, 350 Water Street, Cambridge, MA 02141, USA., Yang S; Merck & Co., Inc., 320 Bent Street, Cambridge, MA 02141, USA., O'Carroll A; GSK, Gunnels Wood Road, Stevenage, UK., Aulchenko YS; GSK, Gunnels Wood Road, Stevenage, UK., Seaton D; GSK, Gunnels Wood Road, Stevenage, UK., Buniello A; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Birney E; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Fauman EB; Pfizer Research & Development, 1 Portland St, Cambridge, MA 02139, USA., McCarthy MI; Genentech, 1 DNA Way, South San Francisco, CA 94080, USA., Hulcoop DG; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Trynka G; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK., McDonagh EM; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK., Ochoa D; Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 May 01. Date of Electronic Publication: 2026 May 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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