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Alleviation of osteoarthritis progression through far-infrared therapy targeting osteoclast cytoskeleton and MAPK/c-Fos/NFATc1 signaling inhibition.

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Title: Alleviation of osteoarthritis progression through far-infrared therapy targeting osteoclast cytoskeleton and MAPK/c-Fos/NFATc1 signaling inhibition.
Authors: Qin B; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China., Lu HA; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Xu XF; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Vascular Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China., Yang JJ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Wang YP; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Breast, Thyroid and Vascular Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China., Zhang HT; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University & Key Laboratory of Regenerative Medicine of Ministry of Education Jinan University, Guangzhou, Guangdong 510630, China., Fu SJ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Qu YQ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Wu WY; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Zheng WY; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Xu YL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Sit CL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Law BYK; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China., Wang N; New Age Technology (Asia) Limited, TML Tower, 3 Hoi Shing Road, Tsuen Wan 999077, Hong Kong, China., Xu Y; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: xywyll@swmu.edu.cn., Wong VKW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Macau University of Science and Technology Innovation Technology Research Institute, 999078, Macao Special Administrative Region of China. Electronic address: kawwong@must.edu.mo.
Source: Pharmacological research [Pharmacol Res] 2026 Jun; Vol. 228, pp. 108221. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Alleviation of osteoarthritis progression through far-infrared therapy targeting osteoclast cytoskeleton and MAPK/c-Fos/NFATc1 signaling inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Qin+B%22">Qin B</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Orthopedics, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China.<br /><searchLink fieldCode="AU" term="%22Lu+HA%22">Lu HA</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Xu+XF%22">Xu XF</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Vascular Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China.<br /><searchLink fieldCode="AU" term="%22Yang+JJ%22">Yang JJ</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Wang+YP%22">Wang YP</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Department of Breast, Thyroid and Vascular Surgery, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan 646600, China.<br /><searchLink fieldCode="AU" term="%22Zhang+HT%22">Zhang HT</searchLink>; Department of Bone and Joint Surgery, the First Affiliated Hospital of Jinan University & Key Laboratory of Regenerative Medicine of Ministry of Education Jinan University, Guangzhou, Guangdong 510630, China.<br /><searchLink fieldCode="AU" term="%22Fu+SJ%22">Fu SJ</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Qu+YQ%22">Qu YQ</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Wu+WY%22">Wu WY</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Zheng+WY%22">Zheng WY</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Xu+YL%22">Xu YL</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Sit+CL%22">Sit CL</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Law+BYK%22">Law BYK</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; New Age Technology (Asia) Limited, TML Tower, 3 Hoi Shing Road, Tsuen Wan 999077, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China. Electronic address: xywyll@swmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wong+VKW%22">Wong VKW</searchLink>; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Mechanism and Quality of Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, 999078, Macao Special Administrative Region of China; Macau University of Science and Technology Innovation Technology Research Institute, 999078, Macao Special Administrative Region of China. Electronic address: kawwong@must.edu.mo.
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  Data: <searchLink fieldCode="JN" term="%228907422%22">Pharmacological research</searchLink> [Pharmacol Res] 2026 Jun; Vol. 228, pp. 108221. <i>Date of Electronic Publication: </i>2026 May 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8907422 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1096-1186 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210436618%22">10436618 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Res <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.phrs.2026.108221
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      – Code: eng
        Text: English
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        StartPage: 108221
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      – TitleFull: Alleviation of osteoarthritis progression through far-infrared therapy targeting osteoclast cytoskeleton and MAPK/c-Fos/NFATc1 signaling inhibition.
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              Text: 2026 Jun
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