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Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial.

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Title: Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial.
Authors: Cooper S; The Royal Marsden NHS Foundation Trust, London, UK sian.cooper@rmh.nhs.uk.; The Institute of Cancer Research, London, UK., Alexander S; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Breitkreutz D; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada., Casey F; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Christodouleas J; Elekta AB, Stockholm, Sweden., Dassen MG; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Dell'acqua V; Elekta AB, Stockholm, Sweden., Dunlop A; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Herbert T; The Royal Marsden NHS Foundation Trust, London, UK., Kolias P; Department of Mathematics, Aristotle University of Thessaloniki, Thessaloniki, Greece., Mitchell A; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK., Pos FJ; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Westley R; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Tree AC; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK., Van Der Heide UA; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Vesprini D; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Source: BMJ open [BMJ Open] 2026 May 07; Vol. 16 (5), pp. e111791. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions (DESTINATION 2): protocol for a randomised, phase II/R-IDEAL2b trial.
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  Data: <searchLink fieldCode="AU" term="%22Cooper+S%22">Cooper S</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK sian.cooper@rmh.nhs.uk.; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Alexander+S%22">Alexander S</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Breitkreutz+D%22">Breitkreutz D</searchLink>; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Casey+F%22">Casey F</searchLink>; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Christodouleas+J%22">Christodouleas J</searchLink>; Elekta AB, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Dassen+MG%22">Dassen MG</searchLink>; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Dell'acqua+V%22">Dell'acqua V</searchLink>; Elekta AB, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Dunlop+A%22">Dunlop A</searchLink>; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Herbert+T%22">Herbert T</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Kolias+P%22">Kolias P</searchLink>; Department of Mathematics, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Mitchell+A%22">Mitchell A</searchLink>; The Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Pos+FJ%22">Pos FJ</searchLink>; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Westley+R%22">Westley R</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Tree+AC%22">Tree AC</searchLink>; The Royal Marsden NHS Foundation Trust, London, UK.; The Institute of Cancer Research, London, UK.<br /><searchLink fieldCode="AU" term="%22Van+Der+Heide+UA%22">Van Der Heide UA</searchLink>; Department of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Vesprini+D%22">Vesprini D</searchLink>; Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
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