Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol.

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Title: Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol.
Authors: Ledingham D; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK david.ledingham1@nhs.net.; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Mills R; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Gibbs M; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Maynes M; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK., Pal A; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK., Iredale R; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK., Foster V; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK., Ong S; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Sathyanarayana S; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Jenkins A; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Nicholson C; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Hussain M; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK., Baker MR; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK., Pavese N; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Aarhus University Hospital Department of Nuclear Medicine & PET-Centre, Aarhus, Denmark.
Source: BMJ open [BMJ Open] 2026 May 07; Vol. 16 (5), pp. e117391. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Observational Study
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol.
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  Data: <searchLink fieldCode="AU" term="%22Ledingham+D%22">Ledingham D</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK david.ledingham1@nhs.net.; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Mills+R%22">Mills R</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Gibbs+M%22">Gibbs M</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Maynes+M%22">Maynes M</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Pal+A%22">Pal A</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Iredale+R%22">Iredale R</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Foster+V%22">Foster V</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Ong+S%22">Ong S</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Sathyanarayana+S%22">Sathyanarayana S</searchLink>; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Jenkins+A%22">Jenkins A</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Nicholson+C%22">Nicholson C</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Hussain+M%22">Hussain M</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Baker+MR%22">Baker MR</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Pavese+N%22">Pavese N</searchLink>; Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.; Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK.; NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK.; Translational and Clinical Research Institute, Aarhus University Hospital Department of Nuclear Medicine & PET-Centre, Aarhus, Denmark.
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