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Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.

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Title: Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.
Authors: Pepper-Tunick E; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA., Srinivas V; Institute for Systems Biology, Seattle, WA, USA., Mast FD; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA., Li S; Seattle Children's Research Institute, Seattle, WA, USA., Russ S; Institute for Systems Biology, Seattle, WA, USA., Hanson W; Institute for Systems Biology, Seattle, WA, USA., Zamora AD; Institute for Systems Biology, Seattle, WA, USA., Wu WJ; Institute for Systems Biology, Seattle, WA, USA., Silcocks M; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia., Thi Minh Ha D; Pham Ngoc Thach Hospital for TB and Lung Disease, Ho Chi Minh City, Vietnam., Dunstan SJ; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia., Nguyen Thuy Thuong T; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK., Turkarslan S; Institute for Systems Biology, Seattle, WA, USA., Aitchison JD; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA., Arrieta-Ortiz ML; Institute for Systems Biology, Seattle, WA, USA. mario.arrieta-ortiz@isbscience.org., Baliga NS; Institute for Systems Biology, Seattle, WA, USA. nitin.baliga@isbscience.org.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Biology, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Microbiology, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Civil & Environmental Engineering, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. nitin.baliga@isbscience.org.
Source: Nature communications [Nat Commun] 2026 May 07; Vol. 17 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Host oxidative stress primes mycobacteria for rapid antibiotic resistance evolution.
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  Data: <searchLink fieldCode="AU" term="%22Pepper-Tunick+E%22">Pepper-Tunick E</searchLink>; Institute for Systems Biology, Seattle, WA, USA.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Srinivas+V%22">Srinivas V</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mast+FD%22">Mast FD</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Russ+S%22">Russ S</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Hanson+W%22">Hanson W</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Zamora+AD%22">Zamora AD</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+WJ%22">Wu WJ</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Silcocks+M%22">Silcocks M</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Thi+Minh+Ha+D%22">Thi Minh Ha D</searchLink>; Pham Ngoc Thach Hospital for TB and Lung Disease, Ho Chi Minh City, Vietnam.<br /><searchLink fieldCode="AU" term="%22Dunstan+SJ%22">Dunstan SJ</searchLink>; Department of Infectious Diseases, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+Thuy+Thuong+T%22">Nguyen Thuy Thuong T</searchLink>; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Turkarslan+S%22">Turkarslan S</searchLink>; Institute for Systems Biology, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Aitchison+JD%22">Aitchison JD</searchLink>; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Arrieta-Ortiz+ML%22">Arrieta-Ortiz ML</searchLink>; Institute for Systems Biology, Seattle, WA, USA. mario.arrieta-ortiz@isbscience.org.<br /><searchLink fieldCode="AU" term="%22Baliga+NS%22">Baliga NS</searchLink>; Institute for Systems Biology, Seattle, WA, USA. nitin.baliga@isbscience.org.; Molecular Engineering and Sciences Institute, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Biology, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Microbiology, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Department of Civil & Environmental Engineering, University of Washington, Seattle, WA, USA. nitin.baliga@isbscience.org.; Lawrence Berkeley National Laboratory, Berkeley, CA, USA. nitin.baliga@isbscience.org.
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