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A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis.

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Title: A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis.
Authors: Li Y; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Huang S; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Chan LS; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Li X; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China., To NS; Hong Kong Center for Neurodegenerative Diseases, Hong Kong SAR, China., Zhao X; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.; College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China., Jung K; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Yang X; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Tse YC; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Xu N; MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China., Xia Y; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China., Cheung TH; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong SAR, China.; State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, China., Qu J; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Mak HY; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China. hym@ust.hk.
Source: Nature communications [Nat Commun] 2026 May 07; Vol. 17 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Chan+LS%22">Chan LS</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22To+NS%22">To NS</searchLink>; Hong Kong Center for Neurodegenerative Diseases, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.; College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, China.<br /><searchLink fieldCode="AU" term="%22Jung+K%22">Jung K</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Tse+YC%22">Tse YC</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Xu+N%22">Xu N</searchLink>; MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cheung+TH%22">Cheung TH</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong SAR, China.; State Key Laboratory of Nervous System Disorders, Daniel and Mayce Yu Molecular Neuroscience Center, Center for Stem Cell Research, The Hong Kong University of Science and Technology, Hong Kong SAR, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Qu+J%22">Qu J</searchLink>; Biophotonics Research Laboratory, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Mak+HY%22">Mak HY</searchLink>; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China. hym@ust.hk.
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              Text: 2026 May 07
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