SLX4IP limits replication stress globally and at ALT telomeres.

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Title: SLX4IP limits replication stress globally and at ALT telomeres.
Authors: Spindler J; Max Planck Institute for Biology of Ageing, Cologne, Germany., Pandolfo F; Max Planck Institute for Biology of Ageing, Cologne, Germany., Koch AE; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Piccirillo P; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Jordahl D; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA., Venkatesh N; Max Planck Institute for Biology of Ageing, Cologne, Germany., Suresh D; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., Ylvisaker KR; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA., Jopkiewicz A; Max Planck Institute for Biology of Ageing, Cologne, Germany., Bihler J; Max Planck Institute for Biology of Ageing, Cologne, Germany., Buschbaum S; Max Planck Institute for Biology of Ageing, Cologne, Germany., Morgenstern M; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA., Overmyer KA; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA., Vincendeau E; Max Planck Institute for Biology of Ageing, Cologne, Germany., Coon JJ; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA., Wei PC; Brain Mosaicism and Tumorigenesis, German Cancer Research Center, Heidelberg, Germany.; Interdisciplinary Center for Neuroscience, Faculty of Biosciences, Heidelberg University, Heidelberg, Germany., Hänsel-Hertsch R; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany.; Institute of Human Genetics, University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany., Mehta KPM; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA. kmehta@wisc.edu., Panier S; Max Planck Institute for Biology of Ageing, Cologne, Germany. panier@age.mpg.de.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany. panier@age.mpg.de.; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany. panier@age.mpg.de.
Source: The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (12), pp. 4176-4219. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: SLX4IP limits replication stress globally and at ALT telomeres.
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  Data: <searchLink fieldCode="AU" term="%22Spindler+J%22">Spindler J</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Pandolfo+F%22">Pandolfo F</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+AE%22">Koch AE</searchLink>; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Piccirillo+P%22">Piccirillo P</searchLink>; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Jordahl+D%22">Jordahl D</searchLink>; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Venkatesh+N%22">Venkatesh N</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Suresh+D%22">Suresh D</searchLink>; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Ylvisaker+KR%22">Ylvisaker KR</searchLink>; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Jopkiewicz+A%22">Jopkiewicz A</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Bihler+J%22">Bihler J</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Buschbaum+S%22">Buschbaum S</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Morgenstern+M%22">Morgenstern M</searchLink>; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Overmyer+KA%22">Overmyer KA</searchLink>; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Vincendeau+E%22">Vincendeau E</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Coon+JJ%22">Coon JJ</searchLink>; Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Wei+PC%22">Wei PC</searchLink>; Brain Mosaicism and Tumorigenesis, German Cancer Research Center, Heidelberg, Germany.; Interdisciplinary Center for Neuroscience, Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hänsel-Hertsch+R%22">Hänsel-Hertsch R</searchLink>; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine, University of Cologne, Cologne, Germany.; Institute of Human Genetics, University Hospital Cologne, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Mehta+KPM%22">Mehta KPM</searchLink>; Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA. kmehta@wisc.edu.<br /><searchLink fieldCode="AU" term="%22Panier+S%22">Panier S</searchLink>; Max Planck Institute for Biology of Ageing, Cologne, Germany. panier@age.mpg.de.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), Cologne, Germany. panier@age.mpg.de.; Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Cologne, Germany. panier@age.mpg.de.
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  Data: <searchLink fieldCode="JN" term="%228208664%22">The EMBO journal</searchLink> [EMBO J] 2026 Jun; Vol. 45 (12), pp. 4176-4219. <i>Date of Electronic Publication: </i>2026 May 07.
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