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Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library.

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Title: Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library.
Authors: Teshima A; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan., Teklemichael AA; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan., Hirata A; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan., Akimoto M; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan., Taniguchi M; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan., Muslimin R; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Department of Biology, Universitas Negeri Makassar, Jl. Dg Tata Raya Parangtambung, Makassar, South Sulawesi, 90223, Indonesia., Ogaki S; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan., Ali A; Department of Biology, Universitas Negeri Makassar, Jl. Dg Tata Raya Parangtambung, Makassar, South Sulawesi, 90223, Indonesia., Suzuki T; Department of Fermentation Sciences, Faculty of Applied Biosciences, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo, 156-8502, Japan., Mizukami S; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan. mizukami@nagasaki-u.ac.jp.; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan. mizukami@nagasaki-u.ac.jp., Arakawa K; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan. karakawa@hiroshima-u.ac.jp.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan. karakawa@hiroshima-u.ac.jp.
Source: The Journal of antibiotics [J Antibiot (Tokyo)] 2026 Jul; Vol. 79 (7), pp. 461-468. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE
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  Data: Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library.
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  Data: <searchLink fieldCode="AU" term="%22Teshima+A%22">Teshima A</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.<br /><searchLink fieldCode="AU" term="%22Teklemichael+AA%22">Teklemichael AA</searchLink>; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+A%22">Hirata A</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.<br /><searchLink fieldCode="AU" term="%22Akimoto+M%22">Akimoto M</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.<br /><searchLink fieldCode="AU" term="%22Taniguchi+M%22">Taniguchi M</searchLink>; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.<br /><searchLink fieldCode="AU" term="%22Muslimin+R%22">Muslimin R</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Department of Biology, Universitas Negeri Makassar, Jl. Dg Tata Raya Parangtambung, Makassar, South Sulawesi, 90223, Indonesia.<br /><searchLink fieldCode="AU" term="%22Ogaki+S%22">Ogaki S</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.<br /><searchLink fieldCode="AU" term="%22Ali+A%22">Ali A</searchLink>; Department of Biology, Universitas Negeri Makassar, Jl. Dg Tata Raya Parangtambung, Makassar, South Sulawesi, 90223, Indonesia.<br /><searchLink fieldCode="AU" term="%22Suzuki+T%22">Suzuki T</searchLink>; Department of Fermentation Sciences, Faculty of Applied Biosciences, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo, 156-8502, Japan.<br /><searchLink fieldCode="AU" term="%22Mizukami+S%22">Mizukami S</searchLink>; Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan. mizukami@nagasaki-u.ac.jp.; School of Tropical Medicine and Global Health, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan. mizukami@nagasaki-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Arakawa+K%22">Arakawa K</searchLink>; Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan. karakawa@hiroshima-u.ac.jp.; Hiroshima Research Center for Healthy Aging (HiHA), Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan. karakawa@hiroshima-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%220151115%22">The Journal of antibiotics</searchLink> [J Antibiot (Tokyo)] 2026 Jul; Vol. 79 (7), pp. 461-468. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0151115 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1881-1469 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200218820%22">00218820 </searchLink><i>NLM ISO Abbreviation: </i>J Antibiot (Tokyo) <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41429-026-00924-0
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      – Code: eng
        Text: English
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        StartPage: 461
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      – TitleFull: Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library.
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              Text: 2026 Jul
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