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Impact of Apolipoprotein E4 on blood-brain barrier integrity in target replacement murine models: a systematic review and meta-analysis.

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Title: Impact of Apolipoprotein E4 on blood-brain barrier integrity in target replacement murine models: a systematic review and meta-analysis.
Authors: Laing KK; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. klaing@ed.ac.uk.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK. klaing@ed.ac.uk.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK. klaing@ed.ac.uk., Fialova N; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK., Wardlaw J; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK., Montagne A; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. axel.montagne@ed.ac.uk.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK. axel.montagne@ed.ac.uk.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK. axel.montagne@ed.ac.uk.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 May 07; Vol. 18 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
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  Data: Impact of Apolipoprotein E4 on blood-brain barrier integrity in target replacement murine models: a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Laing+KK%22">Laing KK</searchLink>; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. klaing@ed.ac.uk.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK. klaing@ed.ac.uk.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK. klaing@ed.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fialova+N%22">Fialova N</searchLink>; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Wardlaw+J%22">Wardlaw J</searchLink>; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Montagne+A%22">Montagne A</searchLink>; UK Dementia Research Institute at the University of Edinburgh, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. axel.montagne@ed.ac.uk.; UK Dementia Research Institute Centre for Vascular Dementia Research, British Heart Foundation, University of Edinburgh, Edinburgh, UK. axel.montagne@ed.ac.uk.; Institute for Neuroscience and Cardiovascular Research (INCR), University of Edinburgh, Chancellor's Building, Edinburgh, UK. axel.montagne@ed.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 May 07; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13195-026-02018-3
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      – TitleFull: Impact of Apolipoprotein E4 on blood-brain barrier integrity in target replacement murine models: a systematic review and meta-analysis.
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              Text: 2026 May 07
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