Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU).

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Title: Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU).
Authors: Philipp R; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany. r.philipp@uke.de., Walbaum C; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Bokemeyer C; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Dinger U; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Härter M; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Hemsen B; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Holsteg S; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Karger A; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany., Koch U; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Kriston L; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Lezius S; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-CPW 1, Hamburg, Germany., Lindner R; Institute of Social Work, University of Kassel, Arnold-Bode-Strasse 10, Kassel, Germany., Maatouk I; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany., Oechsle K; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany., Scholl I; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany., Wagner A; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany., Vehling S; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.
Source: Trials [Trials] 2026 May 07; Vol. 27 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101263253 Publication Model: Electronic Cited Medium: Internet ISSN: 1745-6215 (Electronic) Linking ISSN: 17456215 NLM ISO Abbreviation: Trials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Existential distress in advanced cancer: study protocol of a pragmatic randomized controlled trial of a short-term psychodynamic therapy (ORPHYS) compared to usual psycho-oncological treatment (TAU).
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  Data: <searchLink fieldCode="AU" term="%22Philipp+R%22">Philipp R</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany. r.philipp@uke.de.<br /><searchLink fieldCode="AU" term="%22Walbaum+C%22">Walbaum C</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bokemeyer+C%22">Bokemeyer C</searchLink>; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dinger+U%22">Dinger U</searchLink>; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Härter+M%22">Härter M</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hemsen+B%22">Hemsen B</searchLink>; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Holsteg+S%22">Holsteg S</searchLink>; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Karger+A%22">Karger A</searchLink>; Clinical Institute of Psychosomatic Medicine and Psychotherapy, Medical Faculty & University Hospital Düsseldorf, Heinrich-Heine University, Moorenstr. 5, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Koch+U%22">Koch U</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kriston+L%22">Kriston L</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lezius+S%22">Lezius S</searchLink>; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-CPW 1, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lindner+R%22">Lindner R</searchLink>; Institute of Social Work, University of Kassel, Arnold-Bode-Strasse 10, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Maatouk+I%22">Maatouk I</searchLink>; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Oechsle+K%22">Oechsle K</searchLink>; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Scholl+I%22">Scholl I</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+A%22">Wagner A</searchLink>; Department of Internal Medicine II, Chair of Integrated Psychosomatic Medicine and Psychotherapy, University Hospital Würzburg, Oberdürrbacher Str. 6, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vehling+S%22">Vehling S</searchLink>; Department of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-W26, Hamburg, Germany.; Department of Oncology, Hematology, and Bone Marrow Transplantation with section of Pneumology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-O24, Hamburg, Germany.
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