Protocol for a multicentric open-label randomized controlled trial comparing low-dose (0.25 mg/kg) and standard-dose (0.75 mg/kg) primaquine for gametocytocidal efficacy and safety in Plasmodium falciparum malaria.
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| Title: | Protocol for a multicentric open-label randomized controlled trial comparing low-dose (0.25 mg/kg) and standard-dose (0.75 mg/kg) primaquine for gametocytocidal efficacy and safety in Plasmodium falciparum malaria. |
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| Authors: | Gulati P; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Singhal R; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Gupta A; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Anjali; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Tripathi PK; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Kumar D; Rajendra Institute of Medical Science, Ranchi, Jharkhand, India., Sinha DP; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Singh SP; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Singh K; Late Baliram Kashyap Medical College, Jagdalpur, Chhattisgarh, India., Baharia RK; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Bhatt KN; Government Medical College, Surat, Gujarat, India., Vasava AH; Government Medical College, Surat, Gujarat, India., Gamit A; Government Medical College, Surat, Gujarat, India., Patki MB; Zoram Medical College and Hospital, Aizawl, Mizoram, India., Malla WA; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Kori L; Indian Council of Medical Research, Ansari Nagar, New Delhi, India., Savargaonkar D; Indian Council of Medical Research, Ansari Nagar, New Delhi, India., Chakma N; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Parmar D; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Alagesan L; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Kashyap R; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India., Singh K; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Anvikar AR; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India., Bharti PK; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India. saprapbs@yahoo.co.in.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India. saprapbs@yahoo.co.in., Nitika N; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India. dr.nitika11@gmail.com.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India. dr.nitika11@gmail.com. |
| Source: | Malaria journal [Malar J] 2026 May 07; Vol. 25 (1). Date of Electronic Publication: 2026 May 07. |
| Publication Type: | Clinical Trial Protocol; Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101139802 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-2875 (Electronic) Linking ISSN: 14752875 NLM ISO Abbreviation: Malar J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42098821 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Protocol for a multicentric open-label randomized controlled trial comparing low-dose (0.25 mg/kg) and standard-dose (0.75 mg/kg) primaquine for gametocytocidal efficacy and safety in Plasmodium falciparum malaria. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gulati+P%22">Gulati P</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Singhal+R%22">Singhal R</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Anjali%22">Anjali</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Tripathi+PK%22">Tripathi PK</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Kumar+D%22">Kumar D</searchLink>; Rajendra Institute of Medical Science, Ranchi, Jharkhand, India.<br /><searchLink fieldCode="AU" term="%22Sinha+DP%22">Sinha DP</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Singh+SP%22">Singh SP</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; Late Baliram Kashyap Medical College, Jagdalpur, Chhattisgarh, India.<br /><searchLink fieldCode="AU" term="%22Baharia+RK%22">Baharia RK</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Bhatt+KN%22">Bhatt KN</searchLink>; Government Medical College, Surat, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Vasava+AH%22">Vasava AH</searchLink>; Government Medical College, Surat, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Gamit+A%22">Gamit A</searchLink>; Government Medical College, Surat, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Patki+MB%22">Patki MB</searchLink>; Zoram Medical College and Hospital, Aizawl, Mizoram, India.<br /><searchLink fieldCode="AU" term="%22Malla+WA%22">Malla WA</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Kori+L%22">Kori L</searchLink>; Indian Council of Medical Research, Ansari Nagar, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Savargaonkar+D%22">Savargaonkar D</searchLink>; Indian Council of Medical Research, Ansari Nagar, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Chakma+N%22">Chakma N</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Parmar+D%22">Parmar D</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Alagesan+L%22">Alagesan L</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Kashyap+R%22">Kashyap R</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.<br /><searchLink fieldCode="AU" term="%22Singh+K%22">Singh K</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Anvikar+AR%22">Anvikar AR</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Bharti+PK%22">Bharti PK</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India. saprapbs@yahoo.co.in.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India. saprapbs@yahoo.co.in.<br /><searchLink fieldCode="AU" term="%22Nitika+N%22">Nitika N</searchLink>; ICMR-National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, India. dr.nitika11@gmail.com.; Academy of Scientific and Innovative Research (AcSIR), AcSIR Headquarters CSIR-HRDC Campus, Postal Staff College Area, Sector-19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh, India. dr.nitika11@gmail.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101139802%22">Malaria journal</searchLink> [Malar J] 2026 May 07; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 May 07. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial Protocol; Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101139802 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1475-2875 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214752875%22">14752875 </searchLink><i>NLM ISO Abbreviation: </i>Malar J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42098821 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12936-026-05912-1 Languages: – Code: eng Text: English Titles: – TitleFull: Protocol for a multicentric open-label randomized controlled trial comparing low-dose (0.25 mg/kg) and standard-dose (0.75 mg/kg) primaquine for gametocytocidal efficacy and safety in Plasmodium falciparum malaria. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gulati P – PersonEntity: Name: NameFull: Singhal R – PersonEntity: Name: NameFull: Gupta A – PersonEntity: Name: NameFull: Anjali – PersonEntity: Name: NameFull: Tripathi PK – PersonEntity: Name: NameFull: Kumar D – PersonEntity: Name: NameFull: Sinha DP – PersonEntity: Name: NameFull: Singh SP – PersonEntity: Name: NameFull: Singh K – PersonEntity: Name: NameFull: Baharia RK – PersonEntity: Name: NameFull: Bhatt KN – PersonEntity: Name: NameFull: Vasava AH – PersonEntity: Name: NameFull: Gamit A – PersonEntity: Name: NameFull: Patki MB – PersonEntity: Name: NameFull: Malla WA – PersonEntity: Name: NameFull: Kori L – PersonEntity: Name: NameFull: Savargaonkar D – PersonEntity: Name: NameFull: Chakma N – PersonEntity: Name: NameFull: Parmar D – PersonEntity: Name: NameFull: Alagesan L – PersonEntity: Name: NameFull: Kashyap R – PersonEntity: Name: NameFull: Singh K – PersonEntity: Name: NameFull: Anvikar AR – PersonEntity: Name: NameFull: Bharti PK – PersonEntity: Name: NameFull: Nitika N IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 05 Text: 2026 May 07 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1475-2875 Numbering: – Type: volume Value: 25 – Type: issue Value: 1 Titles: – TitleFull: Malaria journal Type: main |
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