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Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease.

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Title: Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease.
Authors: Tarawneh R; Department of Neurology, Saint Louis University, 1008 S Spring Ave, St Louis, MO, 63110, USA. Rawan.Tarawneh@health.slu.edu., Moulder KL; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA., Topouza DG; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA., Kar A; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA., Qian HT; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA., Pankratz VS; Department of Internal Medicine, Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, NM, 87110, USA., Timsina J; Department of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.; Neuro-Genomics and Informatics Center, Washington University in St Louis, St Louis, MO, 63110, USA., Franklin EE; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, 63110, USA., Schindler SE; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA., Perrin RJ; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA., Ances BM; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, 63110, USA., Benzinger TLS; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, 63110, USA., Hassenstab J; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO, 63110, USA., Morris JC; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA., Holtzman DM; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA., Cruchaga C; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.; Neuro-Genomics and Informatics Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 May 07; Vol. 18 (1). Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Early syndecan-4 upregulation predicts cognitive and pathological trajectories in Alzheimer disease.
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  Data: <searchLink fieldCode="AU" term="%22Tarawneh+R%22">Tarawneh R</searchLink>; Department of Neurology, Saint Louis University, 1008 S Spring Ave, St Louis, MO, 63110, USA. Rawan.Tarawneh@health.slu.edu.<br /><searchLink fieldCode="AU" term="%22Moulder+KL%22">Moulder KL</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Topouza+DG%22">Topouza DG</searchLink>; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA.<br /><searchLink fieldCode="AU" term="%22Kar+A%22">Kar A</searchLink>; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA.<br /><searchLink fieldCode="AU" term="%22Qian+HT%22">Qian HT</searchLink>; Olink Proteomics, Part of Thermo-Fisher Scientific, Boston, MA, 02453, USA.<br /><searchLink fieldCode="AU" term="%22Pankratz+VS%22">Pankratz VS</searchLink>; Department of Internal Medicine, Division of Epidemiology, Biostatistics, and Preventive Medicine, University of New Mexico, Albuquerque, NM, 87110, USA.<br /><searchLink fieldCode="AU" term="%22Timsina+J%22">Timsina J</searchLink>; Department of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.; Neuro-Genomics and Informatics Center, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Franklin+EE%22">Franklin EE</searchLink>; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Schindler+SE%22">Schindler SE</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Perrin+RJ%22">Perrin RJ</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Ances+BM%22">Ances BM</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Benzinger+TLS%22">Benzinger TLS</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Radiology, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Hassenstab+J%22">Hassenstab J</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Washington University in St Louis, St Louis, MO, 63110, USA.; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Knight Washington University Alzheimer Disease Research Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Department of Psychiatry, Washington University in St Louis, St Louis, MO, 63110, USA.; Neuro-Genomics and Informatics Center, Washington University in St Louis, St Louis, MO, 63110, USA.; Hope Center for Neurological Disorders, Washington University in St Louis, St Louis, MO, 63110, USA.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 May 07; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s13195-026-02043-2
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