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Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial.

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Title: Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial.
Authors: Xiong Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Che F; Department of Neurology, Linyi People's Hospital, Linyi, China., Wang H; Department of Neurology, Linyi People's Hospital, Linyi, China., Hao M; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Nguyen TN; Department of Neurology and Radiology, Boston Medical Center, Boston, Massachusetts., Fisher M; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Jin A; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Cao Z; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wang Z; Department of Neurology, Linyi People's Hospital, Linyi, China., Yao X; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China., Feng G; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China., Xu Y; Department of Neurology, Linyi Central Hospital, Linyi, China., Guo S; Department of Neurology, Linyi Central Hospital, Linyi, China., Qin H; Department of Neurology, Zaozhuang Municipal Hospital, Zaozhuang, China., Huang X; Department of Neurology, First Affiliated Hospital of Wannan Medical College, Wuhu, China., Xu J; Department of Neurology, People's Hospital of Queshan, Zhumadian, China., Chen Z; Department of Neurological Intervention and Neurological Intensive Care, Dalian Municipal Central Hospital, Dalian, China., Yuan J; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China., Li W; Department of Neurology, Heze Municipal Hospital, Heze, China., Hu W; Department of Neurology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Feng X; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Zong L; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Ye W; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China., Duan C; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China., Wang L; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Wu S; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Campbell BCV; Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Wang Y; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
Corporate Authors: TNK-PLUS Investigators
Source: JAMA [JAMA] 2026 Jun 02; Vol. 335 (21), pp. 1849-1858.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Clinical Trial, Phase III; Equivalence Trial
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Che+F%22">Che F</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Hao+M%22">Hao M</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Nguyen+TN%22">Nguyen TN</searchLink>; Department of Neurology and Radiology, Boston Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Fisher+M%22">Fisher M</searchLink>; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Jin+A%22">Jin A</searchLink>; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cao+Z%22">Cao Z</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Neurology, Linyi People's Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China.<br /><searchLink fieldCode="AU" term="%22Feng+G%22">Feng G</searchLink>; Department of Neurology, First People's Hospital of Chenzhou, Chenzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Neurology, Linyi Central Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Guo+S%22">Guo S</searchLink>; Department of Neurology, Linyi Central Hospital, Linyi, China.<br /><searchLink fieldCode="AU" term="%22Qin+H%22">Qin H</searchLink>; Department of Neurology, Zaozhuang Municipal Hospital, Zaozhuang, China.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Neurology, First Affiliated Hospital of Wannan Medical College, Wuhu, China.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; Department of Neurology, People's Hospital of Queshan, Zhumadian, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Neurological Intervention and Neurological Intensive Care, Dalian Municipal Central Hospital, Dalian, China.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Neurology, Heze Municipal Hospital, Heze, China.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Department of Neurology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Feng+X%22">Feng X</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zong+L%22">Zong L</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Duan+C%22">Duan C</searchLink>; Department of Neurology, Daxing Teaching Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wu+S%22">Wu S</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Campbell+BCV%22">Campbell BCV</searchLink>; Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Beijing, China.
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