Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.

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Bibliographic Details
Title: Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.
Authors: Otun CW; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Yuen M; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Spacey HJ; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Bawn C; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Cliff MJ; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Falcioni F; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK., Bragg RA; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK., Elmore CS; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg Sweden., Hay S; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Rowbotham JS; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.
Source: Chemical science [Chem Sci] 2026 Apr 24; Vol. 17 (23), pp. 11459-11465. Date of Electronic Publication: 2026 Apr 24 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-6520
DOI:10.1039/d6sc01003b