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Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.

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Title: Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.
Authors: Otun CW; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Yuen M; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Spacey HJ; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Bawn C; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Cliff MJ; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Falcioni F; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK., Bragg RA; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK., Elmore CS; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg Sweden., Hay S; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk., Rowbotham JS; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.
Source: Chemical science [Chem Sci] 2026 Apr 24; Vol. 17 (23), pp. 11459-11465. Date of Electronic Publication: 2026 Apr 24 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Stereoselective hydrogen isotope exchange on nicotinamide cofactors through flavoenzyme microscopic reversibility.
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  Data: <searchLink fieldCode="AU" term="%22Otun+CW%22">Otun CW</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Yuen+M%22">Yuen M</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Spacey+HJ%22">Spacey HJ</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Bawn+C%22">Bawn C</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Cliff+MJ%22">Cliff MJ</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Falcioni+F%22">Falcioni F</searchLink>; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Bragg+RA%22">Bragg RA</searchLink>; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Cambridge UK.<br /><searchLink fieldCode="AU" term="%22Elmore+CS%22">Elmore CS</searchLink>; Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca Gothenburg Sweden.<br /><searchLink fieldCode="AU" term="%22Hay+S%22">Hay S</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Rowbotham+JS%22">Rowbotham JS</searchLink>; Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester Manchester M1 7DN UK jack.rowbotham@manchester.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101545951%22">Chemical science</searchLink> [Chem Sci] 2026 Apr 24; Vol. 17 (23), pp. 11459-11465. <i>Date of Electronic Publication: </i>2026 Apr 24 (<i>Print Publication: </i>2026).
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              Text: 2026 Apr 24
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