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Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).

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Title: Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).
Authors: Hashmi M; Department of Critical Care Medicine, Ziauddin University-Karachi, Sindh, Pakistan., Haniffa R; Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Jayakumar D; Department of Critical Care, Dr Kamakshi Memorial Hospital, Chennai, Tamil Nadu, India., Beane A; Mahidol Oxford Tropical Medicine Research Unit, Bangkok, Thailand.; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom., Lorenzi E; Berry Consultants, Austin, TX., Berry LR; Berry Consultants, Austin, TX., Nasir Khoso M; South City Hospital, Karachi, Pakistan., Ain Khan Q; Critical Care, North Nazimabad Campus, Dr Ziauddin Group of Hospitals, Karachi, Pakistan., Kumar A; Department of Chest Medicine and Critical Care, Ziauddin University, Karachi, Sindh, Pakistan., Altaf Kidwai A; Department of Medicine, Abbasi Shaheed Hospital, Nazimabad, Karachi, Pakistan., Hills TE; Medical Research Institute, Wellington, New Zealand., Annane D; Service de Réanimation médicale et unité de ventilation à domicile, centre de référence neuromusculaire GNHM, CHU Raymond Poincaré, APHP, Université de Versailles Saint Quentin en Yvelines, Garches, France., Aryal D; Nepal Intensive Care Research Foundation, Kathmandu, Nepal., Au C; Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom., Baillie K; Centre for Inflammation Research, Deanery of Clinical Sciences, University of Edinburgh, Midlothian, United Kingdom., Beasley R; Medical Research Institute, Wellington, New Zealand., Best-Lane J; Division of Anaesthetics, Pain Medicine, and Intensive Care, Imperial College London, London, United Kingdom., Bonten M; Department of Medical Microbiology, University Medical Center, Utrecht, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands., Bradbury CA; University of Bristol, Bristol, United Kingdom., Brunkhorst FM; Jena University Hospital, Jena, Germany., Burrell A; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Department of Intensive Care and Hyperbaric Medicine, The Alfred, Melbourne, VIC, Australia., Buxton M; Global Coalition for Adaptive Research, Larkspur, CA., Cecconi M; Department of Anesthesiology and Intensive Care, IRCCS Humanitas Research Hospital, Milan, Italy., Cheng AC; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; Infectious Diseases Unit, Alfred Hospital, Melbourne, VIC, Australia., Cove ME; National University of Singapore, Singapore., de Jong M; Department of Medical Microbiology, University Medical Center, Utrecht, The Netherlands., Detry MA; Berry Consultants, Austin, TX., Duffy E; Auckland City Hospital, Auckland, New Zealand., Estcourt LJ; University of Oxford, Oxford, United Kingdom., Fitzgerald M; Berry Consultants, Austin, TX., Fowler R; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada., Goossens H; Medical Microbiology, Vaccine & Infectious Diseases Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium., Green C; Monash University, Melbourne, VIC, Australia., Hays LMC; University College Dublin Clinical Research Centre, St Vincent's University Hospital, Dublin, Ireland., Higgins AM; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Huang DT; University of Pittsburgh, Pittsburgh, PA., Ichihara N; The University of Tokyo, Bunkyo-ku, Tokyo, Japan., Koirala S; Department of Pulmonary, Critical Care and Sleep Medicine, Hospital for Advanced Medicine and Surgery, Kathmandu, Nepal., Lamontagne F; Universite de Sherbrooke, Sherbrooke, QC, Canada., Lawler PR; McGill University Faculty of Medicine, Montreal, QC, Canada., Lewis RJ; Berry Consultants, Austin, TX., Litton E; The University of Western Australia, Perth, WA, Australia., Mahon N; University College Dublin Clinical Research Centre, St Vincent's University Hospital, Dublin, Ireland., Marshall JC; University of Toronto, Toronto, ON, Canada., McAuley DF; ICU, QUB, Belfast, United Kingdom.; Centre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., McGlothlin A; Berry Consultants, Austin, TX., McGuinness S; Auckland City Hospital, Auckland, New Zealand., McQuilten ZK; Monash University, Melbourne, VIC, Australia., McVerry BJ; Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh Medical Center Health System, Pittsburgh, PA., Mouncey PR; Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom., Morpeth S; Middlemore Hospital, Auckland, New Zealand., Netea M; Radboud Universitair Medisch Centrum, Nijmegen, The Netherlands., Orr K; Fiona Stanley Hospital, Murdoch, WA, Australia., Parke RL; The University of Auckland, Auckland, New Zealand., Parker JC; Monash University, Melbourne, VIC, Australia., Patanwala A; Auckland City Hospital, Auckland, New Zealand.; Royal Prince Alfred Hospital, Camperdown, NSW, Australia., Peters S; European Clinical Research Alliance on Infectious Diseases (Ecraid), Utrecht, The Netherlands., Reyes LF; Universidad de La Sabana, Chia, Colombia., Rowan KM; Clinical Trials Unit, Intensive Care National Audit & Research Centre, London, United Kingdom., Saito H; St Marianna University School of Medicine, Kawasaki, Kanagawa, Japan., Saunders CT; Berry Consultants, Austin, TX., Santos M; Unity Health Toronto, Toronto, ON, Canada., Seymour CW; University of Pittsburgh, Pittsburgh, PA., Shankar-Hari M; Centre for Inflammation Research, The University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, United Kingdom., Singh V; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia., Slater M; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia., Tambyah PA; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tong SYC; The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia., Turgeon AF; Universite Laval, Quebec, QC, Canada., Turner AM; Medical Research Institute, Wellington, New Zealand., van de Veerdonk F; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Weis S; Institute for Infectious Disease and Infection Control, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI), Jena, Germany., Zarychanski R; University of Manitoba, Winnipeg, MB, Canada., McArthur CJ; Auckland City Hospital, Auckland, New Zealand., Angus DC; University of Pittsburgh, Pittsburgh, PA., Berry SM; Berry Consultants, Austin, TX., Gordon AC; Imperial College London, London, United Kingdom., Derde LPG; Intensive Care Center, University Medical Centre, Utrecht, The Netherlands., Webb SA; Monash University, Clayton, VIC, Australia., Murthy S; The University of British Columbia, Vancouver, BC, Canada., Arabi Y; Critical Care, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia., Nichol AD; Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.; University College Dublin Clinical Research Centre, St Vincent's University Hospital, Dublin, Ireland.
Corporate Authors: and the Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) Investigators
Source: Critical care medicine [Crit Care Med] 2026 Jul 01; Vol. 54 (7), pp. 1546-1562. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article; Randomized Controlled Trial; Adaptive Clinical Trial
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0355501 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0293 (Electronic) Linking ISSN: 00903493 NLM ISO Abbreviation: Crit Care Med Subsets: MEDLINE
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  Data: Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).
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Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tong+SYC%22">Tong SYC</searchLink>; The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Turgeon+AF%22">Turgeon AF</searchLink>; Universite Laval, Quebec, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Turner+AM%22">Turner AM</searchLink>; Medical Research Institute, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22van+de+Veerdonk+F%22">van de Veerdonk F</searchLink>; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Weis+S%22">Weis S</searchLink>; Institute for Infectious Disease and Infection Control, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University, Jena, Germany.; 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  Data: <searchLink fieldCode="JN" term="%220355501%22">Critical care medicine</searchLink> [Crit Care Med] 2026 Jul 01; Vol. 54 (7), pp. 1546-1562. <i>Date of Electronic Publication: </i>2026 May 08.
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      – TitleFull: Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP).
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    IsPartOfRelationships:
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          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1530-0293
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 7
          Titles:
            – TitleFull: Critical care medicine
              Type: main
ResultId 1