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The Sonic Hedgehog Pathway is Activated in Cushing's Disease with USP8 Mutations.

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Title: The Sonic Hedgehog Pathway is Activated in Cushing's Disease with USP8 Mutations.
Authors: Huang S; Department of Neurosurgery, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China., Xu Y; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China., Zhou X; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China., Lu J; Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200050, China., Cao X; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China. caoxiaoyun2594@163.com.
Source: Biochemical genetics [Biochem Genet] 2026 May 08. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The Sonic Hedgehog Pathway is Activated in Cushing's Disease with USP8 Mutations.
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  Data: <searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Neurosurgery, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200050, China.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Neurosurgical Institute of Fudan University, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Shanghai Clinical Medical Center of Neurosurgery, Shanghai, 200040, China. caoxiaoyun2594@163.com.; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, 200040, China. caoxiaoyun2594@163.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic%2FPlenum+Publishers%22">Kluwer Academic/Plenum Publishers </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0126611 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-4927 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200062928%22">00062928 </searchLink><i>NLM ISO Abbreviation: </i>Biochem Genet <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s10528-026-11383-5
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      – Code: eng
        Text: English
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      – TitleFull: The Sonic Hedgehog Pathway is Activated in Cushing's Disease with USP8 Mutations.
        Type: main
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          Name:
            NameFull: Huang S
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            NameFull: Xu Y
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            NameFull: Zhou X
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            NameFull: Lu J
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          Name:
            NameFull: Cao X
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          Dates:
            – D: 08
              M: 05
              Text: 2026 May 08
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1573-4927
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            – TitleFull: Biochemical genetics
              Type: main
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