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Inhibition of endothelial S1PR2 preserves blood-brain barrier integrity after traumatic brain injury through activating the PI3K-AKT signaling pathway.

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Title: Inhibition of endothelial S1PR2 preserves blood-brain barrier integrity after traumatic brain injury through activating the PI3K-AKT signaling pathway.
Authors: Cheng H; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Wang Q; Department of Laboratory Medicine, Hebei Provincial Peoples Hospital, Shijiazhuang, 050051, China., Men Y; Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., An Y; Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Ma B; Department of Neurosurgery, The 82nd Group Hospital of PLA Army, Baoding, 071000, China., Dai S; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Jing Z; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., He X; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Bao X; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Long Y; Department of Neurosurgery, The Cangzhou Central Hospital, Cangzhou, 061000, China., Yu J; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China., Wu Y; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China. 28704926@hebmu.edu.cn., Sun G; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China. sungzh705@163.com.
Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2026 Jun; Vol. 481 (6), pp. 2497-2514. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibition of endothelial S1PR2 preserves blood-brain barrier integrity after traumatic brain injury through activating the PI3K-AKT signaling pathway.
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  Data: <searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Laboratory Medicine, Hebei Provincial Peoples Hospital, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Men+Y%22">Men Y</searchLink>; Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22An+Y%22">An Y</searchLink>; Emergency Department, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Ma+B%22">Ma B</searchLink>; Department of Neurosurgery, The 82nd Group Hospital of PLA Army, Baoding, 071000, China.<br /><searchLink fieldCode="AU" term="%22Dai+S%22">Dai S</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Jing+Z%22">Jing Z</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22He+X%22">He X</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Bao+X%22">Bao X</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Long+Y%22">Long Y</searchLink>; Department of Neurosurgery, The Cangzhou Central Hospital, Cangzhou, 061000, China.<br /><searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China. 28704926@hebmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Sun+G%22">Sun G</searchLink>; Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050051, China. sungzh705@163.com.
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  Data: <searchLink fieldCode="JN" term="%220364456%22">Molecular and cellular biochemistry</searchLink> [Mol Cell Biochem] 2026 Jun; Vol. 481 (6), pp. 2497-2514. <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0364456 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-4919 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203008177%22">03008177 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cell Biochem <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11010-026-05546-6
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              Text: 2026 Jun
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