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Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation.

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Title: Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation.
Authors: Saha G; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Anchi P; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Wang R; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Biondo A; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Meyer S; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Kondragunta V; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Luchsinger LL; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580., Syed I; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Deaconess Medical Center and Harvard Medical School, Boston, MA 02115., Sharif H; Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 127788, United Arab Emirates., Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115., Giri Magupalli V; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 May 12; Vol. 123 (19), pp. e2537563123. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation.
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  Data: <searchLink fieldCode="AU" term="%22Saha+G%22">Saha G</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Anchi+P%22">Anchi P</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Biondo+A%22">Biondo A</searchLink>; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Meyer+S%22">Meyer S</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Kondragunta+V%22">Kondragunta V</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Luchsinger+LL%22">Luchsinger LL</searchLink>; Laboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.<br /><searchLink fieldCode="AU" term="%22Syed+I%22">Syed I</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Deaconess Medical Center and Harvard Medical School, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Sharif+H%22">Sharif H</searchLink>; Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 127788, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115.<br /><searchLink fieldCode="AU" term="%22Giri+Magupalli+V%22">Giri Magupalli V</searchLink>; Laboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 May 12; Vol. 123 (19), pp. e2537563123. <i>Date of Electronic Publication: </i>2026 May 08.
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              Text: 2026 May 12
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