The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis.

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Title: The pleuroparenchymal fibroelastosis atlas reveals aberrant cell states and their zonation as an alternate roadmap to lung fibrosis.
Authors: Ruwisch J; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany., Cazes A; Département de Pathologie, Hôpital Bichat-Claude Bernard, AP-HP and Université Paris Cité, INSERM U1149, CRI, Paris, France., Leiber LM; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Borie R; Service de Pneumologie, Allergologie et Transplantation, AP-HP, Hôpital Bichat, F-75018 Paris, France.; Université Paris Cité, Inserm, UMR 1149, Centre de Recherche de l'Inflammation, F-75018 Paris, France., Neubert L; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School, Hannover, Germany., Christian L; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Thomas de Montpréville V; Institute of Pathology, Marie Lannelongue Hospital, Le Plessis-Robinson, France., Szmul A; Satsuma Lab, Hawkes Institute, University College London, London, UK., Moussa F; UMR 6030-ISTCT-CNRS, Normandy University, Caen, France., Verleden SE; Department of Antwerp Surgical Training, Anatomy and Research Centre, Faculty of Medicine, University of Antwerp, Wilrijk, Belgium., Gaedcke S; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Hegermann J; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Functional and Applied Anatomy, Research Core Unit Electron Microscopy, Hannover Medical School, Hannover, Germany., Fuge J; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Ballmaier M; Central Research Facility Cell Sorting, Hannover Medical School, Hannover, Germany., Kamp JC; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School, Hannover, Germany., Greer M; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Braubach P; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School, Hannover, Germany., Werlein C; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Pathology, Hannover Medical School, Hannover, Germany., Ius F; Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany., Graalmann T; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Junior Research Group Translational Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany., Aburahma K; Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany., De Sadeleer LJ; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Unit for Interstitial Lung Diseases, Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Egashira R; Satsuma Lab, Hawkes Institute, University College London, London, UK., Ackermann M; Institute of Pathology, Hannover Medical School, Hannover, Germany.; Institute of Pathology, Aachen Medical University, RWTH, Aachen, Germany., Yamada D; Satsuma Lab, Hawkes Institute, University College London, London, UK., Hoeper MM; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Falk C; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany., Gottlieb J; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Schiller HB; Institute of Lung Biology and Disease and Comprehensive Pneumology Center with the CPC-M bioArchive, Helmholtz Zentrum Muenchen, Member of the German Center for Lung Research (DZL), Munich, Germany., Vanaudenaerde B; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Seeliger B; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Debray MP; Service de Radiologie, Hôpital Bichat, APHP; UMR Inserm 1149, CRI; FHU INFIRE, Paris, France., Bernaudin JF; Faculty of Medicine, Sorbonne Université, Paris, France., Knudsen L; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany., Bergot E; Department of Pulmonary Medicine, Regional ILD Expert Center, University Hospital of Caen, Caen, France., Jacob J; Satsuma Lab, Hawkes Institute, University College London, London, UK.; UCL Respiratory, University College London, London, UK., Mal H; Service de Pneumologie B et Transplantation, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Paris, France., Jonigk D; Institute of Pathology, Hannover Medical School, Hannover, Germany.; Institute of Pathology, Aachen Medical University, RWTH, Aachen, Germany., Dettmer S; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany., Mordant P; Assistance Publique-Hôpitaux de Paris, Service de Chirurgie Thoracique, Hôpital Bichat; INSERM, Unité 1152; Université Paris Diderot, Paris, France., Prasse A; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; Department of Biomedicine, University of Basel, Basel, Switzerland., Fadel E; Department of Thoracic Surgery and Heart-Lung transplantation, Université Paris-Saclay, Marie Lannelongue Hospital, Le Plessis Robinson, France., Wuyts WA; Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.; Unit for Interstitial Lung Diseases, Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Crestani B; Service de Pneumologie, Allergologie et Transplantation, AP-HP, Hôpital Bichat, F-75018 Paris, France.; Université Paris Cité, Inserm, UMR 1149, Centre de Recherche de l'Inflammation, F-75018 Paris, France., Kaminski N; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Justet A; UMR 6030-ISTCT-CNRS, Normandy University, Caen, France.; Department of Pulmonary Medicine, Regional ILD Expert Center, University Hospital of Caen, Caen, France.; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA., Schupp JC; Clinic for Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.; Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, CT, USA.
Source: Science advances [Sci Adv] 2026 May 08; Vol. 12 (19), pp. eaeb5967. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.aeb5967