Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.

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Title: Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.
Authors: Villar-Vesga J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., De Feo D; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Clément P; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bugada V; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Meuffels E; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Van Hove H; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bijnen M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., King J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Grundschober S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Ulutekin C; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Pena-Francesch M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Costa-Pereira S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Oberbichler L; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Gogoleva V; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Kim J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Schmidt KW; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bhat MA; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Greis D; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Seehusen F; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland., Prisco F; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland., Dalvi U; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Benke D; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland., Schreiner B; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Ingelfinger F; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Internal Medicine I, Medical Center-University of Freiburg, Freiburg, Germany., Arnold IC; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Münz C; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Greter M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Saab AS; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland., Becher B; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Mundt S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland.
Source: Science immunology [Sci Immunol] 2026 May 08; Vol. 11 (119), pp. eadw5197. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2470-9468
DOI:10.1126/sciimmunol.adw5197