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Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.

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Title: Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.
Authors: Villar-Vesga J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., De Feo D; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Clément P; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bugada V; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Meuffels E; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Van Hove H; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bijnen M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., King J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Grundschober S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Ulutekin C; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Pena-Francesch M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Costa-Pereira S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Oberbichler L; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Gogoleva V; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Kim J; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Schmidt KW; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Bhat MA; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Greis D; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Seehusen F; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland., Prisco F; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland., Dalvi U; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Benke D; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland., Schreiner B; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland., Patriarchi T; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland., Ingelfinger F; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Internal Medicine I, Medical Center-University of Freiburg, Freiburg, Germany., Arnold IC; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Münz C; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Greter M; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Saab AS; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland., Becher B; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland., Mundt S; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland.
Source: Science immunology [Sci Immunol] 2026 May 08; Vol. 11 (119), pp. eadw5197. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: Monocyte-derived macrophages drive neurological tissue damage through mitochondrial reactive oxygen species.
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  Data: <searchLink fieldCode="AU" term="%22Villar-Vesga+J%22">Villar-Vesga J</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22De+Feo+D%22">De Feo D</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Clément+P%22">Clément P</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bugada+V%22">Bugada V</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Meuffels+E%22">Meuffels E</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Van+Hove+H%22">Van Hove H</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bijnen+M%22">Bijnen M</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22King+J%22">King J</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Grundschober+S%22">Grundschober S</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ulutekin+C%22">Ulutekin C</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pena-Francesch+M%22">Pena-Francesch M</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Costa-Pereira+S%22">Costa-Pereira S</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Oberbichler+L%22">Oberbichler L</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gogoleva+V%22">Gogoleva V</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schmidt+KW%22">Schmidt KW</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bhat+MA%22">Bhat MA</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Greis+D%22">Greis D</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Seehusen+F%22">Seehusen F</searchLink>; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Prisco+F%22">Prisco F</searchLink>; Laboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Dalvi+U%22">Dalvi U</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Benke+D%22">Benke D</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Schreiner+B%22">Schreiner B</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Patriarchi+T%22">Patriarchi T</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ingelfinger+F%22">Ingelfinger F</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.; Department of Internal Medicine I, Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Arnold+IC%22">Arnold IC</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Münz+C%22">Münz C</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Greter+M%22">Greter M</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Saab+AS%22">Saab AS</searchLink>; Institute of Pharmacology and Toxicology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Becher+B%22">Becher B</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mundt+S%22">Mundt S</searchLink>; Institute of Experimental Immunology, University of Zurich, Zürich, Switzerland.; Neuroscience Center Zurich, University and ETH, Zürich, Switzerland.; Department of Neurology, University Hospital Zurich, Zürich, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%22101688624%22">Science immunology</searchLink> [Sci Immunol] 2026 May 08; Vol. 11 (119), pp. eadw5197. <i>Date of Electronic Publication: </i>2026 May 08.
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