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Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.

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Title: Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
Authors: Lin XM; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: lin.xiaoming@zsxmhospital.com., Zhang LF; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: zhang.lianfang@zsxmhospital.com., Yi JL; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: m15079499029@163.com., Lin TC; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: 2677232079@qq.com., Xie RC; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: xie.rongcheng@zsxmhospital.com., Tu SW; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: tu.shengwen@zsxmhospital.com., Yi LT; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: litaoyi@hqu.edu.cn., Ma JF; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China. Electronic address: ma.jiefei@zs-hospital.sh.cn.
Source: Journal of ethnopharmacology [J Ethnopharmacol] 2026 Sep 15; Vol. 368, pp. 121827. Date of Electronic Publication: 2026 May 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
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  Data: <searchLink fieldCode="AU" term="%22Lin+XM%22">Lin XM</searchLink>; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: lin.xiaoming@zsxmhospital.com.<br /><searchLink fieldCode="AU" term="%22Zhang+LF%22">Zhang LF</searchLink>; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: zhang.lianfang@zsxmhospital.com.<br /><searchLink fieldCode="AU" term="%22Yi+JL%22">Yi JL</searchLink>; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: m15079499029@163.com.<br /><searchLink fieldCode="AU" term="%22Lin+TC%22">Lin TC</searchLink>; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: 2677232079@qq.com.<br /><searchLink fieldCode="AU" term="%22Xie+RC%22">Xie RC</searchLink>; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: xie.rongcheng@zsxmhospital.com.<br /><searchLink fieldCode="AU" term="%22Tu+SW%22">Tu SW</searchLink>; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China. Electronic address: tu.shengwen@zsxmhospital.com.<br /><searchLink fieldCode="AU" term="%22Yi+LT%22">Yi LT</searchLink>; Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, 361021, Fujian province, PR China. Electronic address: litaoyi@hqu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ma+JF%22">Ma JF</searchLink>; Department of Critical Care Medicine, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, 361015, Fujian province, PR China; Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China. Electronic address: ma.jiefei@zs-hospital.sh.cn.
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  Data: <searchLink fieldCode="JN" term="%227903310%22">Journal of ethnopharmacology</searchLink> [J Ethnopharmacol] 2026 Sep 15; Vol. 368, pp. 121827. <i>Date of Electronic Publication: </i>2026 May 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Sequoia%22">Elsevier Sequoia </searchLink><i>Country of Publication: </i>Ireland <i>NLM ID: </i>7903310 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1872-7573 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203788741%22">03788741 </searchLink><i>NLM ISO Abbreviation: </i>J Ethnopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jep.2026.121827
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      – Code: eng
        Text: English
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      – TitleFull: Integrated network pharmacology, transcriptomics analysis and experimental validation elucidated the underlying mechanisms of Siwu Decoction in the treatment of LPS-induced acute lung injury.
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            NameFull: Tu SW
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            – D: 15
              M: 09
              Text: 2026 Sep 15
              Type: published
              Y: 2026
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