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CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials.

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Title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials.
Authors: Bourgeois W; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Rice HE; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Wenge DV; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany., Perner F; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany., Yue H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Regalado BD; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Wan G; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Schroeder JC; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Sommerschield A; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Singh S; Syngene International Limited, Bangalore, India., Singh S; Syngene International Limited, Bangalore, India., Bijpuria S; Syngene International Limited, Bangalore, India., McKeever BM; Brian M. McKeever, LLC, Lake Ronkonkoma, NY, USA., Miller WH; MedChem Innovations, LLC, Collegeville, PA, USA., Safer JF; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Iqbal S; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Fischer ES; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McGeehan GM; Syndax Pharmaceuticals, Inc, Waltham, MA, USA., Cutler JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. cutlerj@ohsu.edu.; Departments of Pediatrics and Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University (OHSU), Portland, OR, USA. cutlerj@ohsu.edu., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. Scott_Armstrong@dfci.harvard.edu.
Source: Nature communications [Nat Commun] 2026 May 09; Vol. 17 (1). Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials.
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  Data: <searchLink fieldCode="AU" term="%22Bourgeois+W%22">Bourgeois W</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rice+HE%22">Rice HE</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wenge+DV%22">Wenge DV</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Perner+F%22">Perner F</searchLink>; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Yue+H%22">Yue H</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Regalado+BD%22">Regalado BD</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wan+G%22">Wan G</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schroeder+JC%22">Schroeder JC</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sommerschield+A%22">Sommerschield A</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hatton+C%22">Hatton C</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Syngene International Limited, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Syngene International Limited, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22Bijpuria+S%22">Bijpuria S</searchLink>; Syngene International Limited, Bangalore, India.<br /><searchLink fieldCode="AU" term="%22McKeever+BM%22">McKeever BM</searchLink>; Brian M. McKeever, LLC, Lake Ronkonkoma, NY, USA.<br /><searchLink fieldCode="AU" term="%22Miller+WH%22">Miller WH</searchLink>; MedChem Innovations, LLC, Collegeville, PA, USA.<br /><searchLink fieldCode="AU" term="%22Safer+JF%22">Safer JF</searchLink>; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Iqbal+S%22">Iqbal S</searchLink>; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Perry+JA%22">Perry JA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fischer+ES%22">Fischer ES</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doench+JG%22">Doench JG</searchLink>; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22McGeehan+GM%22">McGeehan GM</searchLink>; Syndax Pharmaceuticals, Inc, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cutler+JA%22">Cutler JA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. cutlerj@ohsu.edu.; Departments of Pediatrics and Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University (OHSU), Portland, OR, USA. cutlerj@ohsu.edu.<br /><searchLink fieldCode="AU" term="%22Armstrong+SA%22">Armstrong SA</searchLink>; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. Scott_Armstrong@dfci.harvard.edu.
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