CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials.
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| Title: | CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. |
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| Authors: | Bourgeois W; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Rice HE; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Wenge DV; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany., Perner F; Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Hannover, Germany., Yue H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Regalado BD; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Wan G; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Schroeder JC; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Sommerschield A; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Singh S; Syngene International Limited, Bangalore, India., Singh S; Syngene International Limited, Bangalore, India., Bijpuria S; Syngene International Limited, Bangalore, India., McKeever BM; Brian M. McKeever, LLC, Lake Ronkonkoma, NY, USA., Miller WH; MedChem Innovations, LLC, Collegeville, PA, USA., Safer JF; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Iqbal S; Ladders To Cures Accelerator, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Fischer ES; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., McGeehan GM; Syndax Pharmaceuticals, Inc, Waltham, MA, USA., Cutler JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. cutlerj@ohsu.edu.; Departments of Pediatrics and Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University (OHSU), Portland, OR, USA. cutlerj@ohsu.edu., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute; Division of Hematology/Oncology, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. Scott_Armstrong@dfci.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2026 May 09; Vol. 17 (1). Date of Electronic Publication: 2026 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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