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Mesenchymal stem cell derived exosomes mitigate COVID-19 cytokine storm via Annexin A1 and TGF-β mediated MAPK pathway inhibition.

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Title: Mesenchymal stem cell derived exosomes mitigate COVID-19 cytokine storm via Annexin A1 and TGF-β mediated MAPK pathway inhibition.
Authors: Ebrahim N; Department of Medical Histology and Cell Biology Faculty of Medicine, Benha University, Benha, Egypt.; Stem Cell Unit, Faculty of Medicine, Benha National University, Al Obour City, Egypt.; Keele University, Keele, UK., Al Saihati HA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Albatin, Hafar Al Batin, Saudi Arabia. hajirsh@uhb.edu.sa., Dessouky AA; Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ismail YM; Department of Clinical Pharmacology, Hashemite University, Zarqa, Hashemite Kingdom of Jordan., Shamaa AA; Professor of Surgery, Anesthesiology & Radiology. Faculty of Vet. Men, Cairo University, P. O. Box 12211, Giza, Egypt., Mohamed SA; Department of Genetics and Genetic Engineering, Faculty of Agriculture, Benha University, Benha, Egypt., Mohamed ME; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, 11597, Riyadh, Saudi Arabia., Nosseir N; Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates., Eladl MA; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates., Di Leva G; School of Life Sciences, Keele University Staffordshire, Keele, ST5 5BG, UK., Badr OA; Department of Genetics and Genetic Engineering, Faculty of Agriculture, Benha University, Benha, Egypt. omnia.badr@fagr.bu.edu.eg.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 May 08; Vol. 17 (1). Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
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  Data: Mesenchymal stem cell derived exosomes mitigate COVID-19 cytokine storm via Annexin A1 and TGF-β mediated MAPK pathway inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Ebrahim+N%22">Ebrahim N</searchLink>; Department of Medical Histology and Cell Biology Faculty of Medicine, Benha University, Benha, Egypt.; Stem Cell Unit, Faculty of Medicine, Benha National University, Al Obour City, Egypt.; Keele University, Keele, UK.<br /><searchLink fieldCode="AU" term="%22Al+Saihati+HA%22">Al Saihati HA</searchLink>; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hafr Albatin, Hafar Al Batin, Saudi Arabia. hajirsh@uhb.edu.sa.<br /><searchLink fieldCode="AU" term="%22Dessouky+AA%22">Dessouky AA</searchLink>; Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.<br /><searchLink fieldCode="AU" term="%22Ismail+YM%22">Ismail YM</searchLink>; Department of Clinical Pharmacology, Hashemite University, Zarqa, Hashemite Kingdom of Jordan.<br /><searchLink fieldCode="AU" term="%22Shamaa+AA%22">Shamaa AA</searchLink>; Professor of Surgery, Anesthesiology & Radiology. Faculty of Vet. Men, Cairo University, P. O. Box 12211, Giza, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+SA%22">Mohamed SA</searchLink>; Department of Genetics and Genetic Engineering, Faculty of Agriculture, Benha University, Benha, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+ME%22">Mohamed ME</searchLink>; Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, 11597, Riyadh, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Nosseir+N%22">Nosseir N</searchLink>; Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Eladl+MA%22">Eladl MA</searchLink>; Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.<br /><searchLink fieldCode="AU" term="%22Di+Leva+G%22">Di Leva G</searchLink>; School of Life Sciences, Keele University Staffordshire, Keele, ST5 5BG, UK.<br /><searchLink fieldCode="AU" term="%22Badr+OA%22">Badr OA</searchLink>; Department of Genetics and Genetic Engineering, Faculty of Agriculture, Benha University, Benha, Egypt. omnia.badr@fagr.bu.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%22101527581%22">Stem cell research & therapy</searchLink> [Stem Cell Res Ther] 2026 May 08; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101527581 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1757-6512 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217576512%22">17576512 </searchLink><i>NLM ISO Abbreviation: </i>Stem Cell Res Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 May 08
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