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Antidepressant use and risk of bipolar disorder in children, adolescents and young adults with unipolar depression: a target trial emulation study.

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Title: Antidepressant use and risk of bipolar disorder in children, adolescents and young adults with unipolar depression: a target trial emulation study.
Authors: Fang CZ; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Chan JKN; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Solmi M; SCIENCES lab, Department of Psychiatry, University of Ott awa, Ottawa, Ontario, Canada; Department of Mental Health, The Ottawa Hospital, Ontario, Canada; Ottawa Hospital Research Institute (OHRI) Ottawa Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany., Correll CU; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA; German Center for Mental Health (DZPG), partner site Berlin, Berlin, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany., Wong CSM; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Lo HKY; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong., Chang WC; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong. Electronic address: changwc@hku.hk.
Source: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2026 May 08; Vol. 111, pp. 112862. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Antidepressant use and risk of bipolar disorder in children, adolescents and young adults with unipolar depression: a target trial emulation study.
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  Data: <searchLink fieldCode="AU" term="%22Fang+CZ%22">Fang CZ</searchLink>; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Chan+JKN%22">Chan JKN</searchLink>; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Solmi+M%22">Solmi M</searchLink>; SCIENCES lab, Department of Psychiatry, University of Ott awa, Ottawa, Ontario, Canada; Department of Mental Health, The Ottawa Hospital, Ontario, Canada; Ottawa Hospital Research Institute (OHRI) Ottawa Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; The Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY, USA; Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry and Molecular Medicine, Hempstead, NY, USA; German Center for Mental Health (DZPG), partner site Berlin, Berlin, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wong+CSM%22">Wong CSM</searchLink>; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Lo+HKY%22">Lo HKY</searchLink>; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.<br /><searchLink fieldCode="AU" term="%22Chang+WC%22">Chang WC</searchLink>; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong. Electronic address: changwc@hku.hk.
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  Data: <searchLink fieldCode="JN" term="%229111390%22">European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology</searchLink> [Eur Neuropsychopharmacol] 2026 May 08; Vol. 111, pp. 112862. <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9111390 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-7862 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220924977X%22">0924977X </searchLink><i>NLM ISO Abbreviation: </i>Eur Neuropsychopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.euroneuro.2026.112862
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              Text: 2026 May 08
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