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Brain signatures of childhood trauma and polygenic scores for mental health drive clinical subtypes in depression: a UK Biobank study.

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Title: Brain signatures of childhood trauma and polygenic scores for mental health drive clinical subtypes in depression: a UK Biobank study.
Authors: Cazzella T; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy. Electronic address: t.cazzella@studenti.unisr.it., Fortaner-Uyà L; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Colombo F; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Monopoli C; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Italy., Fabbri C; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Benedetti F; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy., Vai B; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.
Source: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2026 May 08; Vol. 111, pp. 112861. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Brain signatures of childhood trauma and polygenic scores for mental health drive clinical subtypes in depression: a UK Biobank study.
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  Data: <searchLink fieldCode="AU" term="%22Cazzella+T%22">Cazzella T</searchLink>; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy. Electronic address: t.cazzella@studenti.unisr.it.<br /><searchLink fieldCode="AU" term="%22Fortaner-Uyà+L%22">Fortaner-Uyà L</searchLink>; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Colombo+F%22">Colombo F</searchLink>; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Monopoli+C%22">Monopoli C</searchLink>; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Serretti+A%22">Serretti A</searchLink>; Department of Medicine and Surgery, Kore University of Enna, Italy.<br /><searchLink fieldCode="AU" term="%22Fabbri+C%22">Fabbri C</searchLink>; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Benedetti+F%22">Benedetti F</searchLink>; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vai+B%22">Vai B</searchLink>; Vita-Salute San Raffaele University, Milan, Italy; Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, IRCCS Ospedale San Raffaele, Milan, Italy.
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  Data: <searchLink fieldCode="JN" term="%229111390%22">European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology</searchLink> [Eur Neuropsychopharmacol] 2026 May 08; Vol. 111, pp. 112861. <i>Date of Electronic Publication: </i>2026 May 08.
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