Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.

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Title: Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.
Authors: Carlini NA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Hanson BE; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Ruple BA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Craig JC; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Fermoyle CC; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Faculty of Medicine and Health, University of Sydney, Australia., McKenzie AI; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Bisconti AV; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Pelka EZ; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Supiano MA; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States., Tuday E; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Division of Cardiology, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT, United States., Richardson RS; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States., Drummond MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, United States; Molecular Medicine Program, University of Utah, Salt Lake City, UT, United States., Rajasekaran NS; Cardiac Aging and Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology/Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, United States., Broxterman RM; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States., Trinity JD; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States. Electronic address: joel.trinity@hscutah.edu.
Source: Free radical biology & medicine [Free Radic Biol Med] 2026 May 07; Vol. 254, pp. 827-841. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE
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  Data: Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.
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  Data: <searchLink fieldCode="AU" term="%22Carlini+NA%22">Carlini NA</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Hanson+BE%22">Hanson BE</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Ruple+BA%22">Ruple BA</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Craig+JC%22">Craig JC</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Fermoyle+CC%22">Fermoyle CC</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Faculty of Medicine and Health, University of Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22McKenzie+AI%22">McKenzie AI</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Bisconti+AV%22">Bisconti AV</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Pelka+EZ%22">Pelka EZ</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Supiano+MA%22">Supiano MA</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Tuday+E%22">Tuday E</searchLink>; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Division of Cardiology, Department of Internal Medicine, The University of Utah School of Medicine, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Richardson+RS%22">Richardson RS</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Drummond+MJ%22">Drummond MJ</searchLink>; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT, United States; Molecular Medicine Program, University of Utah, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Rajasekaran+NS%22">Rajasekaran NS</searchLink>; Cardiac Aging and Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology/Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, United States.<br /><searchLink fieldCode="AU" term="%22Broxterman+RM%22">Broxterman RM</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States.<br /><searchLink fieldCode="AU" term="%22Trinity+JD%22">Trinity JD</searchLink>; Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States; Geriatric Research, Education, and Clinical Center, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, United States; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, United States. Electronic address: joel.trinity@hscutah.edu.
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  Data: <searchLink fieldCode="JN" term="%228709159%22">Free radical biology & medicine</searchLink> [Free Radic Biol Med] 2026 May 07; Vol. 254, pp. 827-841. <i>Date of Electronic Publication: </i>2026 May 07.
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