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Vδ1 T cells exhibit high lactic acid resistance and antitumor activity in solid tumors.

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Title: Vδ1 T cells exhibit high lactic acid resistance and antitumor activity in solid tumors.
Authors: Su Y; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China., Liu C; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China., Li C; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China., Cai M; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China., Xu Y; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China., Hu Y; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China., Chen H; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. chenhui_1980@126.com.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China. chenhui_1980@126.com.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China. chenhui_1980@126.com., Zhang J; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. jzhang42@163.com.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China. jzhang42@163.com.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China. jzhang42@163.com., He W; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. hewei@pumc.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 May 09; Vol. 24 (1). Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Vδ1 T cells exhibit high lactic acid resistance and antitumor activity in solid tumors.
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  Data: <searchLink fieldCode="AU" term="%22Su+Y%22">Su Y</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Cai+M%22">Cai M</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China.<br /><searchLink fieldCode="AU" term="%22Hu+Y%22">Hu Y</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. chenhui_1980@126.com.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China. chenhui_1980@126.com.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China. chenhui_1980@126.com.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. jzhang42@163.com.; Beijing Jiadehe Cell Therapy Technology Co., Ltd, Beijing, China. jzhang42@163.com.; Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, Jiangsu, 213000, China. jzhang42@163.com.<br /><searchLink fieldCode="AU" term="%22He+W%22">He W</searchLink>; Department of Immunology, CAMS Key Laboratory T cell and Cancer Immunotherapy, Institute of Basic Medical Sciences, School of Basic Medicine, State Key Laboratory of Common Mechanism Research for Major Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100005, China. hewei@pumc.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 May 09; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 May 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1186/s12967-026-08234-7
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        Text: English
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      – TitleFull: Vδ1 T cells exhibit high lactic acid resistance and antitumor activity in solid tumors.
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          Name:
            NameFull: Su Y
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          Name:
            NameFull: Liu C
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            NameFull: Chen H
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            – D: 09
              M: 05
              Text: 2026 May 09
              Type: published
              Y: 2026
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              Value: 24
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