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Tilorone suppresses TGF-β-driven fibroblast activation and restores BMP-Smad1/5/8 signaling: implications for laryngotracheal fibrosis.

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Title: Tilorone suppresses TGF-β-driven fibroblast activation and restores BMP-Smad1/5/8 signaling: implications for laryngotracheal fibrosis.
Authors: Toth E; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.; Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary., Szabo K; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary., Vegh AG; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary., Zvara A; Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary., Puskas LG; Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary., Bach A; Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary., Migh E; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary., Horvath P; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary.; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Institute of AI for Health, Helmholtz Zentrum München, Neuherberg, Germany., Tiszlavicz L; Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary., Rovo L; Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary., Keller-Pinter A; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.; Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.; Department of Internal Medicine, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.
Source: Journal of translational medicine [J Transl Med] 2026 May 09. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Tilorone suppresses TGF-β-driven fibroblast activation and restores BMP-Smad1/5/8 signaling: implications for laryngotracheal fibrosis.
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  Data: <searchLink fieldCode="AU" term="%22Toth+E%22">Toth E</searchLink>; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.; Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Szabo+K%22">Szabo K</searchLink>; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Vegh+AG%22">Vegh AG</searchLink>; Institute of Biophysics, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Zvara+A%22">Zvara A</searchLink>; Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Puskas+LG%22">Puskas LG</searchLink>; Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Bach+A%22">Bach A</searchLink>; Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Migh+E%22">Migh E</searchLink>; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Horvath+P%22">Horvath P</searchLink>; Synthetic and Systems Biology Unit, HUN-REN Biological Research Centre, Szeged, Hungary.; Single-Cell Technologies Ltd, Szeged, Hungary.; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Institute of AI for Health, Helmholtz Zentrum München, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Tiszlavicz+L%22">Tiszlavicz L</searchLink>; Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Rovo+L%22">Rovo L</searchLink>; Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary.<br /><searchLink fieldCode="AU" term="%22Keller-Pinter+A%22">Keller-Pinter A</searchLink>; Department of Biochemistry, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.; Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.; Department of Internal Medicine, Albert Szent-Gyorgyi Medical School, University of Szeged, Szeged, Hungary. keller.aniko@med.u-szeged.hu.
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              Text: 2026 May 09
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