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Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics.

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Title: Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics.
Authors: Li YR; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Chiang PY; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan., Hou SY; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan., Lin CH; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan., Lo LC; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. Electronic address: lclo@ntu.edu.tw., Fu SL; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: slfu@nycu.edu.tw.
Source: Bioorganic chemistry [Bioorg Chem] 2026 Aug 15; Vol. 178, pp. 109946. Date of Electronic Publication: 2026 May 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics.
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  Data: <searchLink fieldCode="AU" term="%22Li+YR%22">Li YR</searchLink>; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiang+PY%22">Chiang PY</searchLink>; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hou+SY%22">Hou SY</searchLink>; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan; Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lo+LC%22">Lo LC</searchLink>; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan. Electronic address: lclo@ntu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Fu+SL%22">Fu SL</searchLink>; Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan. Electronic address: slfu@nycu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 Aug 15; Vol. 178, pp. 109946. <i>Date of Electronic Publication: </i>2026 May 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2026.109946
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      – Code: eng
        Text: English
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      – TitleFull: Design, synthesis, and evaluation of novel andrographolide derivatives as anti-pancreatic cancer therapeutics.
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              Text: 2026 Aug 15
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