Impact of introducing RTS,S/AS01E malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme.
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| Title: | Impact of introducing RTS,S/AS01 |
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| Authors: | Mwapasa V; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Asante KP; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: kwakupoku.asante@kintampo-hrc.org., Milligan P; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: paul.milligan@lshtm.ac.uk., Akech S; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Global Health Center, Centers for Disease Control and Prevention, Kisumu, Kenya., Oduro A; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Ghana., Mathanga DP; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Fogelson A; London School of Hygiene & Tropical Medicine, London, UK., Kwambai TK; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya., Hamel MJ; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland., Kapito-Tembo A; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Gyan T; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Westercamp N; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Okine RNA; Global Malaria Programme, WHO, Geneva, Switzerland., Moore KA; London School of Hygiene & Tropical Medicine, London, UK; Murdoch Children's Research Institute, Infection and Immunity, New Vaccines, VIC, Australia., Pellaux-Furrer E; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland., Stanley CC; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Ansong D; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Kariuki S; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., Njuguna P; Global Malaria Programme, WHO, Geneva, Switzerland; PATH Center for Vaccine Innovation and Access, Nairobi, Kenya., Mvalo T; University of North Carolina Project-Malawi, Lilongwe, Malawi., Welaga P; C K Tedam University of Technology and Applied Sciences, Navrongo, Ghana., Otieno L; Kenya Medical Research Institute-United States Army Medical Research Directorate-Africa, Kisumu, Kenya., Snell P; London School of Hygiene & Tropical Medicine, London, UK., Schellenberg D; Global Malaria Programme, WHO, Geneva, Switzerland., Chimala A; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Afari EA; School of Public Health, University of Ghana, Accra, Ghana., Bejon P; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Maleta K; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Agbenyega T; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Snow RW; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK., Zulu M; University of North Carolina Project-Malawi, Lilongwe, Malawi., Odei-Lartey E; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana., Chinkhumba J; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi., Samuels AM; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. |
| Corporate Authors: | Malaria Vaccine Programme Evaluation partners |
| Source: | Lancet (London, England) [Lancet] 2026 May 09; Vol. 407 (10541), pp. 1796-1808. |
| Publication Type: | Journal Article; Observational Study |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42107373 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of introducing RTS,S/AS01<subscript>E</subscript> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Mwapasa+V%22">Mwapasa V</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Asante+KP%22">Asante KP</searchLink>; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: kwakupoku.asante@kintampo-hrc.org.<br /><searchLink fieldCode="AU" term="%22Milligan+P%22">Milligan P</searchLink>; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: paul.milligan@lshtm.ac.uk.<br /><searchLink fieldCode="AU" term="%22Akech+S%22">Akech S</searchLink>; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Global Health Center, Centers for Disease Control and Prevention, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Oduro+A%22">Oduro A</searchLink>; Navrongo Health Research Centre, Research and Development Division, Ghana Health Service, Ghana.<br /><searchLink fieldCode="AU" term="%22Mathanga+DP%22">Mathanga DP</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Fogelson+A%22">Fogelson A</searchLink>; London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Kwambai+TK%22">Kwambai TK</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Hamel+MJ%22">Hamel MJ</searchLink>; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Kapito-Tembo+A%22">Kapito-Tembo A</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Gyan+T%22">Gyan T</searchLink>; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.<br /><searchLink fieldCode="AU" term="%22Westercamp+N%22">Westercamp N</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Okine+RNA%22">Okine RNA</searchLink>; Global Malaria Programme, WHO, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Moore+KA%22">Moore KA</searchLink>; London School of Hygiene & Tropical Medicine, London, UK; Murdoch Children's Research Institute, Infection and Immunity, New Vaccines, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Pellaux-Furrer+E%22">Pellaux-Furrer E</searchLink>; Department of Immunizations, Vaccines, and Biologicals, WHO, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stanley+CC%22">Stanley CC</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Ansong+D%22">Ansong D</searchLink>; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Kariuki+S%22">Kariuki S</searchLink>; Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Njuguna+P%22">Njuguna P</searchLink>; Global Malaria Programme, WHO, Geneva, Switzerland; PATH Center for Vaccine Innovation and Access, Nairobi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mvalo+T%22">Mvalo T</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi.<br /><searchLink fieldCode="AU" term="%22Welaga+P%22">Welaga P</searchLink>; C K Tedam University of Technology and Applied Sciences, Navrongo, Ghana.<br /><searchLink fieldCode="AU" term="%22Otieno+L%22">Otieno L</searchLink>; Kenya Medical Research Institute-United States Army Medical Research Directorate-Africa, Kisumu, Kenya.<br /><searchLink fieldCode="AU" term="%22Snell+P%22">Snell P</searchLink>; London School of Hygiene & Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Schellenberg+D%22">Schellenberg D</searchLink>; Global Malaria Programme, WHO, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Chimala+A%22">Chimala A</searchLink>; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Afari+EA%22">Afari EA</searchLink>; School of Public Health, University of Ghana, Accra, Ghana.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maleta+K%22">Maleta K</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Agbenyega+T%22">Agbenyega T</searchLink>; Agogo Malaria Research Centre, Agogo, Ghana; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.<br /><searchLink fieldCode="AU" term="%22Snow+RW%22">Snow RW</searchLink>; Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zulu+M%22">Zulu M</searchLink>; University of North Carolina Project-Malawi, Lilongwe, Malawi.<br /><searchLink fieldCode="AU" term="%22Odei-Lartey+E%22">Odei-Lartey E</searchLink>; Kintampo Health Research Centre, Research and Development Division, Ghana Health Service, Kintampo North Municipality, Ghana.<br /><searchLink fieldCode="AU" term="%22Chinkhumba+J%22">Chinkhumba J</searchLink>; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi; Malaria Alert Centre, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Samuels+AM%22">Samuels AM</searchLink>; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Kisumu, Kenya; Malaria Branch, Division of Parasitic Diseases and Malaria, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22Malaria+Vaccine+Programme+Evaluation+partners%22">Malaria Vaccine Programme Evaluation partners</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2026 May 09; Vol. 407 (10541), pp. 1796-1808. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Observational Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985213R <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-547X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201406736%22">01406736 </searchLink><i>NLM ISO Abbreviation: </i>Lancet <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42107373 |
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