View in EDS

Update to RIFM fragrance ingredient safety assessment, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS Registry Number 63500-71-0.

Saved in:
Bibliographic Details
Title: Update to RIFM fragrance ingredient safety assessment, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS Registry Number 63500-71-0.
Authors: Api AM; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Bartlett A; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Belsito D; Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA., Botelho D; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Bruze M; Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden., Bryant-Friedrich A; Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI, 48202, USA., Burton GA Jr; Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA., Cancellieri MA; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Chon H; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Cronin M; Member Expert Panel for Fragrance Safety, Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Liverpool, United Kingdom., Crotty S; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Dagli ML; Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil., Dekant W; Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany., Deodhar C; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Farrell K; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Fryer AD; Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA., Jones L; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Joshi K; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Lapczynski A; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Laskin DL; Member Expert Panel for Fragrance Safety, Rutgers University Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA., Lavelle M; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Lee I; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Moustakas H; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Muldoon J; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Penning TM; Member Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA., Piersma AH; Member Expert Panel for Fragrance Safety, Utrecht University, Institute for Risk Assessment Sciences (IRAS), Netherlands., Ritacco G; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Sadekar N; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Schember I; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Schultz TW; Member Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA., Siddiqi F; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA., Sipes IG; Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA., Sullivan G; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA. Electronic address: gsullivan@rifm.org., Thakkar Y; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Source: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2026 Jul; Vol. 213 Suppl 1, pp. 116146. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8207483 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6351 (Electronic) Linking ISSN: 02786915 NLM ISO Abbreviation: Food Chem Toxicol Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42107591
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Update to RIFM fragrance ingredient safety assessment, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS Registry Number 63500-71-0.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Api+AM%22">Api AM</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Bartlett+A%22">Bartlett A</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Belsito+D%22">Belsito D</searchLink>; Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.<br /><searchLink fieldCode="AU" term="%22Botelho+D%22">Botelho D</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Bruze+M%22">Bruze M</searchLink>; Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.<br /><searchLink fieldCode="AU" term="%22Bryant-Friedrich+A%22">Bryant-Friedrich A</searchLink>; Member Expert Panel for Fragrance Safety, Pharmaceutical Sciences, Wayne State University, 42 W. Warren Ave., Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Burton+GA+Jr%22">Burton GA Jr</searchLink>; Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.<br /><searchLink fieldCode="AU" term="%22Cancellieri+MA%22">Cancellieri MA</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Chon+H%22">Chon H</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Cronin+M%22">Cronin M</searchLink>; Member Expert Panel for Fragrance Safety, Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Liverpool, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Crotty+S%22">Crotty S</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Dagli+ML%22">Dagli ML</searchLink>; Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP 05508-900, Brazil.<br /><searchLink fieldCode="AU" term="%22Dekant+W%22">Dekant W</searchLink>; Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Deodhar+C%22">Deodhar C</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Farrell+K%22">Farrell K</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Fryer+AD%22">Fryer AD</searchLink>; Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.<br /><searchLink fieldCode="AU" term="%22Jones+L%22">Jones L</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+K%22">Joshi K</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Lapczynski+A%22">Lapczynski A</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Laskin+DL%22">Laskin DL</searchLink>; Member Expert Panel for Fragrance Safety, Rutgers University Ernest Mario School of Pharmacy, Department of Pharmacology and Toxicology, 160 Frelinghuysen Road, Piscataway, NJ, 08854, USA.<br /><searchLink fieldCode="AU" term="%22Lavelle+M%22">Lavelle M</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Lee+I%22">Lee I</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Moustakas+H%22">Moustakas H</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Muldoon+J%22">Muldoon J</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Penning+TM%22">Penning TM</searchLink>; Member Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.<br /><searchLink fieldCode="AU" term="%22Piersma+AH%22">Piersma AH</searchLink>; Member Expert Panel for Fragrance Safety, Utrecht University, Institute for Risk Assessment Sciences (IRAS), Netherlands.<br /><searchLink fieldCode="AU" term="%22Ritacco+G%22">Ritacco G</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Sadekar+N%22">Sadekar N</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Schember+I%22">Schember I</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Schultz+TW%22">Schultz TW</searchLink>; Member Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.<br /><searchLink fieldCode="AU" term="%22Siddiqi+F%22">Siddiqi F</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.<br /><searchLink fieldCode="AU" term="%22Sipes+IG%22">Sipes IG</searchLink>; Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.<br /><searchLink fieldCode="AU" term="%22Sullivan+G%22">Sullivan G</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA. Electronic address: gsullivan@rifm.org.<br /><searchLink fieldCode="AU" term="%22Thakkar+Y%22">Thakkar Y</searchLink>; Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%228207483%22">Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association</searchLink> [Food Chem Toxicol] 2026 Jul; Vol. 213 Suppl 1, pp. 116146. <i>Date of Electronic Publication: </i>2026 May 08.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8207483 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-6351 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202786915%22">02786915 </searchLink><i>NLM ISO Abbreviation: </i>Food Chem Toxicol <i>Subsets: </i>MEDLINE; In Process
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42107591
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.fct.2026.116146
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 116146
    Titles:
      – TitleFull: Update to RIFM fragrance ingredient safety assessment, 2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol, CAS Registry Number 63500-71-0.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Api AM
      – PersonEntity:
          Name:
            NameFull: Bartlett A
      – PersonEntity:
          Name:
            NameFull: Belsito D
      – PersonEntity:
          Name:
            NameFull: Botelho D
      – PersonEntity:
          Name:
            NameFull: Bruze M
      – PersonEntity:
          Name:
            NameFull: Bryant-Friedrich A
      – PersonEntity:
          Name:
            NameFull: Burton GA Jr
      – PersonEntity:
          Name:
            NameFull: Cancellieri MA
      – PersonEntity:
          Name:
            NameFull: Chon H
      – PersonEntity:
          Name:
            NameFull: Cronin M
      – PersonEntity:
          Name:
            NameFull: Crotty S
      – PersonEntity:
          Name:
            NameFull: Dagli ML
      – PersonEntity:
          Name:
            NameFull: Dekant W
      – PersonEntity:
          Name:
            NameFull: Deodhar C
      – PersonEntity:
          Name:
            NameFull: Farrell K
      – PersonEntity:
          Name:
            NameFull: Fryer AD
      – PersonEntity:
          Name:
            NameFull: Jones L
      – PersonEntity:
          Name:
            NameFull: Joshi K
      – PersonEntity:
          Name:
            NameFull: Lapczynski A
      – PersonEntity:
          Name:
            NameFull: Laskin DL
      – PersonEntity:
          Name:
            NameFull: Lavelle M
      – PersonEntity:
          Name:
            NameFull: Lee I
      – PersonEntity:
          Name:
            NameFull: Moustakas H
      – PersonEntity:
          Name:
            NameFull: Muldoon J
      – PersonEntity:
          Name:
            NameFull: Penning TM
      – PersonEntity:
          Name:
            NameFull: Piersma AH
      – PersonEntity:
          Name:
            NameFull: Ritacco G
      – PersonEntity:
          Name:
            NameFull: Sadekar N
      – PersonEntity:
          Name:
            NameFull: Schember I
      – PersonEntity:
          Name:
            NameFull: Schultz TW
      – PersonEntity:
          Name:
            NameFull: Siddiqi F
      – PersonEntity:
          Name:
            NameFull: Sipes IG
      – PersonEntity:
          Name:
            NameFull: Sullivan G
      – PersonEntity:
          Name:
            NameFull: Thakkar Y
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 07
              Text: 2026 Jul
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1873-6351
          Numbering:
            – Type: volume
              Value: 213 Suppl 1
          Titles:
            – TitleFull: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
              Type: main
ResultId 1