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Restoration of mitochondrial Ca2+ and redox homeostasis by enhancement of SK channels rescues Ca2+ cycling in HFpEF cardiomyocytes.

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Title: Restoration of mitochondrial Ca2+ and redox homeostasis by enhancement of SK channels rescues Ca2+ cycling in HFpEF cardiomyocytes.
Authors: Hamilton S; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: shannahamilton@arizona.edu., Terentyeva R; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Veress R; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Perger F; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Loyo V; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA., Gorr MW; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Surgery, Division of Cardiac Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA., Owusu-Sarfo J; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA; Departement of Surgery, Alpert Medical School of Brown University, Providence, RI, USA., Quiggle S; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA., Gyorke S; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Scherr D; Department of Cardiology, Medical University of Graz, Graz, Austria., Clements RT; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA; Departement of Surgery, Alpert Medical School of Brown University, Providence, RI, USA., Ljubojevic-Holzer S; Department of Cardiology, Medical University of Graz, Graz, Austria; Gottfried Schatz Research Center, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; BioTechMed Graz, Austria., Radwański PB; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Division of Outcomes and Translational Sciences, The Ohio State University, Columbus, OH, USA., Singh H; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Terentyev D; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: dmitry.terentyev@osumc.edu., Belevych AE; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: andriy.belevych@osumc.edu.
Source: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2026 Jul; Vol. 216, pp. 1-12. Date of Electronic Publication: 2026 May 08.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 0262322 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8584 (Electronic) Linking ISSN: 00222828 NLM ISO Abbreviation: J Mol Cell Cardiol Subsets: MEDLINE
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  Data: Restoration of mitochondrial Ca<superscript>2+</superscript> and redox homeostasis by enhancement of SK channels rescues Ca<superscript>2+</superscript> cycling in HFpEF cardiomyocytes.
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  Data: <searchLink fieldCode="AU" term="%22Hamilton+S%22">Hamilton S</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA. Electronic address: shannahamilton@arizona.edu.<br /><searchLink fieldCode="AU" term="%22Terentyeva+R%22">Terentyeva R</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Veress+R%22">Veress R</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Perger+F%22">Perger F</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Loyo+V%22">Loyo V</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Gorr+MW%22">Gorr MW</searchLink>; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Surgery, Division of Cardiac Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Owusu-Sarfo+J%22">Owusu-Sarfo J</searchLink>; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA; Departement of Surgery, Alpert Medical School of Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Quiggle+S%22">Quiggle S</searchLink>; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Gyorke+S%22">Gyorke S</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Scherr+D%22">Scherr D</searchLink>; Department of Cardiology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Clements+RT%22">Clements RT</searchLink>; Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA; Departement of Surgery, Alpert Medical School of Brown University, Providence, RI, USA.<br /><searchLink fieldCode="AU" term="%22Ljubojevic-Holzer+S%22">Ljubojevic-Holzer S</searchLink>; Department of Cardiology, Medical University of Graz, Graz, Austria; Gottfried Schatz Research Center, Division of Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria; BioTechMed Graz, Austria.<br /><searchLink fieldCode="AU" term="%22Radwański+PB%22">Radwański PB</searchLink>; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Division of Outcomes and Translational Sciences, The Ohio State University, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Singh+H%22">Singh H</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Terentyev+D%22">Terentyev D</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: dmitry.terentyev@osumc.edu.<br /><searchLink fieldCode="AU" term="%22Belevych+AE%22">Belevych AE</searchLink>; Department of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA; Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address: andriy.belevych@osumc.edu.
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  Data: <searchLink fieldCode="JN" term="%220262322%22">Journal of molecular and cellular cardiology</searchLink> [J Mol Cell Cardiol] 2026 Jul; Vol. 216, pp. 1-12. <i>Date of Electronic Publication: </i>2026 May 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0262322 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-8584 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222828%22">00222828 </searchLink><i>NLM ISO Abbreviation: </i>J Mol Cell Cardiol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.yjmcc.2026.05.004
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        Text: English
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      – TitleFull: Restoration of mitochondrial Ca2+ and redox homeostasis by enhancement of SK channels rescues Ca2+ cycling in HFpEF cardiomyocytes.
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