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PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.

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Title: PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.
Authors: Butcko AJ; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA., Adeshina KA; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA., Kamali P; Wayne State University School of Medicine, Detroit, MI, USA., Teskey G; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA., Rahman AA; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA., Jaster JV; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA., Tiwari N; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA., Singh NK; Department of Ophthalmology Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA., Granneman JG; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48202, USA., Mottillo EP; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA. emottil1@hfhs.org.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA. emottil1@hfhs.org.
Source: Scientific reports [Sci Rep] 2026 May 10; Vol. 16 (1). Date of Electronic Publication: 2026 May 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: PNPLA3-I148M reduces hepatic triacylglycerol secretion and mitigates diet induced left ventricular diastolic dysfunction.
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  Data: <searchLink fieldCode="AU" term="%22Butcko+AJ%22">Butcko AJ</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Adeshina+KA%22">Adeshina KA</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Kamali+P%22">Kamali P</searchLink>; Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Teskey+G%22">Teskey G</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Rahman+AA%22">Rahman AA</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Jaster+JV%22">Jaster JV</searchLink>; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Tiwari+N%22">Tiwari N</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Singh+NK%22">Singh NK</searchLink>; Department of Ophthalmology Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA.<br /><searchLink fieldCode="AU" term="%22Granneman+JG%22">Granneman JG</searchLink>; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48202, USA.<br /><searchLink fieldCode="AU" term="%22Mottillo+EP%22">Mottillo EP</searchLink>; Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, 6135 Woodward Ave, Detroit, MI, 48202, USA. emottil1@hfhs.org.; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, 48202, USA. emottil1@hfhs.org.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 May 10; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 May 10.
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        Value: 10.1038/s41598-026-47839-2
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              Text: 2026 May 10
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