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TREM2 promotes adipogenesis of PDGFR-α+ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity.

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Title: TREM2 promotes adipogenesis of PDGFR-α+ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity.
Authors: Dobrijevic A; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Korosec A; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Brunner JS; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Matejovicova L; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Gemza A; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Lakovits K; Research Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Lam HS; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Agirre-Lizaso A; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria., Schabbauer G; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria., Knapp S; Research Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Sharif O; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Apr 23; Vol. 17, pp. 1738472. Date of Electronic Publication: 2026 Apr 23 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TREM2 promotes adipogenesis of PDGFR-α<superscript>+</superscript> adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity.
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  Data: <searchLink fieldCode="AU" term="%22Dobrijevic+A%22">Dobrijevic A</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Korosec+A%22">Korosec A</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Brunner+JS%22">Brunner JS</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Matejovicova+L%22">Matejovicova L</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gemza+A%22">Gemza A</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lakovits+K%22">Lakovits K</searchLink>; Research Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Lam+HS%22">Lam HS</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Agirre-Lizaso+A%22">Agirre-Lizaso A</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Schabbauer+G%22">Schabbauer G</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Knapp+S%22">Knapp S</searchLink>; Research Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sharif+O%22">Sharif O</searchLink>; Institute of Vascular Biology and Thrombosis Research, Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.; Christian Doppler Laboratory for Immunometabolism and Systems Biology of Obesity-Related Diseases (InSpiReD)., Vienna, Austria.
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  Data: <searchLink fieldCode="JN" term="%22101555782%22">Frontiers in endocrinology</searchLink> [Front Endocrinol (Lausanne)] 2026 Apr 23; Vol. 17, pp. 1738472. <i>Date of Electronic Publication: </i>2026 Apr 23 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101555782 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1664-2392 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216642392%22">16642392 </searchLink><i>NLM ISO Abbreviation: </i>Front Endocrinol (Lausanne) <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr 23
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