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Silver(I) and Copper(II) complexes of 1,10-phenanthroline-5,6-dione inhibit Sporothrix brasiliensis azole-resistant clinical isolates.

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Title: Silver(I) and Copper(II) complexes of 1,10-phenanthroline-5,6-dione inhibit Sporothrix brasiliensis azole-resistant clinical isolates.
Authors: de Souza LCDSV; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Saquarema Campus, Vassouras University, Saquarema, Rio de Janeiro, Brazil., Reis NF; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Alcântara LM; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Brito SCP; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., de Souza PM; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., de Freitas ZMF; Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Sousa IS; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil., Silva JRS; Centre for Biological and Health Sciences, Federal Sergipe University, São Cristóvão, Sergipe, Brazil., Machado RLD; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Mora-Montes HM; Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, Noria Alta, Mexico., Kneipp LF; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil.; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., McCann M; Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Ireland., Devereux M; Center for Biomimetics and Therapeutics Research, Focas Research Institute, University of Technology, Dublin, Ireland., Dos Santos ALS; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Advanced Studies of Emerging and Resistant Microorganisms, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Baptista ARS; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Source: PeerJ [PeerJ] 2026 May 06; Vol. 14, pp. e21129. Date of Electronic Publication: 2026 May 06 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: PeerJ Inc Country of Publication: United States NLM ID: 101603425 Publication Model: eCollection Cited Medium: Internet ISSN: 2167-8359 (Electronic) Linking ISSN: 21678359 NLM ISO Abbreviation: PeerJ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Silver(I) and Copper(II) complexes of 1,10-phenanthroline-5,6-dione inhibit Sporothrix brasiliensis azole-resistant clinical isolates.
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  Data: <searchLink fieldCode="AU" term="%22de+Souza+LCDSV%22">de Souza LCDSV</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Saquarema Campus, Vassouras University, Saquarema, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Reis+NF%22">Reis NF</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Alcântara+LM%22">Alcântara LM</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Brito+SCP%22">Brito SCP</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Souza+PM%22">de Souza PM</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Freitas+ZMF%22">de Freitas ZMF</searchLink>; Galenic Development Laboratory, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Sousa+IS%22">Sousa IS</searchLink>; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+JRS%22">Silva JRS</searchLink>; Centre for Biological and Health Sciences, Federal Sergipe University, São Cristóvão, Sergipe, Brazil.<br /><searchLink fieldCode="AU" term="%22Machado+RLD%22">Machado RLD</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Mora-Montes+HM%22">Mora-Montes HM</searchLink>; Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato, Noria Alta, Mexico.<br /><searchLink fieldCode="AU" term="%22Kneipp+LF%22">Kneipp LF</searchLink>; Laboratory of Taxonomy, Biochemistry and Bioprospecting of Fungi, Oswaldo Cruz Institute, Rio de Janeiro, Rio de Janeiro, Brazil.; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22McCann+M%22">McCann M</searchLink>; Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Ireland.<br /><searchLink fieldCode="AU" term="%22Devereux+M%22">Devereux M</searchLink>; Center for Biomimetics and Therapeutics Research, Focas Research Institute, University of Technology, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+ALS%22">Dos Santos ALS</searchLink>; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Laboratory of Advanced Studies of Emerging and Resistant Microorganisms, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Baptista+ARS%22">Baptista ARS</searchLink>; Center for Microorganisms' Investigation, Microbiology and Parasitology Department, Biomedical Institute, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Rede Micologia RJ, Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
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