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Mannose-modified IL-10 mRNA nanoparticle delivery system promotes M2 macrophage polarization and ameliorates early immune dysregulation in sepsis.

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Title: Mannose-modified IL-10 mRNA nanoparticle delivery system promotes M2 macrophage polarization and ameliorates early immune dysregulation in sepsis.
Authors: Rao Q; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China., Pan B; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China., Peng Z; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China., Yu Q; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China., Yu Y; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China. yyl@enzemed.com., Wang H; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China. whj@enzemed.com.
Source: Drug delivery and translational research [Drug Deliv Transl Res] 2026 May 11. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mannose-modified IL-10 mRNA nanoparticle delivery system promotes M2 macrophage polarization and ameliorates early immune dysregulation in sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Rao+Q%22">Rao Q</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Pan+B%22">Pan B</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Peng+Z%22">Peng Z</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Yu+Q%22">Yu Q</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China. yyl@enzemed.com.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Anesthesiology, Taizhou Hospital of Zhejiang Province Affiliated With Wenzhou Medical University, No. 150, Ximen Street, Linhai, Taizhou, 317000, Zhejiang Province, China. whj@enzemed.com.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101540061 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2190-3948 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222190393X%22">2190393X </searchLink><i>NLM ISO Abbreviation: </i>Drug Deliv Transl Res <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s13346-026-02107-8
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      – Code: eng
        Text: English
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      – TitleFull: Mannose-modified IL-10 mRNA nanoparticle delivery system promotes M2 macrophage polarization and ameliorates early immune dysregulation in sepsis.
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            NameFull: Rao Q
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            NameFull: Peng Z
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            – D: 11
              M: 05
              Text: 2026 May 11
              Type: published
              Y: 2026
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              Value: 2190-3948
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            – TitleFull: Drug delivery and translational research
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