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ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer.

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Title: ATM Deficiency Induces TGFβ-Mediated Stromal Programming in Pancreatic Cancer.
Authors: Roger E; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Mummey HM; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California., Zimmer E; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Srinivasan D; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Härle A; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Moubri L; Cancer Research Center of Marseille (CRCM) , INSERM U1068, CNRS UMR 7258, Aix-Marseille University and Paoli-Calmettes Institute, Marseille, France., Michels AK; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.; Department of Molecular Biology and Biochemistry, University of California, Irvine, California., Singh R; Department of Molecular Biology and Biochemistry, University of California, Irvine, California., Ekizce M; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Melzer MK; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.; Department of Urology, Ulm University Hospital, Ulm, Germany., Lee Y; Department of Pediatrics, University of California, San Diego, La Jolla, California., Silva A; Department of Molecular Biology and Biochemistry, University of California, Irvine, California., Härle L; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Engleitner T; Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Technische Universität München, Munich, Germany., Arnold F; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Morawe M; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Naggay BK; School of Life Sciences, Reutlingen University, Reutlingen, Germany., Schneider J; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany., Gilberg L; Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Technische Universität München, Munich, Germany., Mosler JP; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Ludwig C; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), School of Life Sciences, Technical University of Munich, Freising, Germany., Meng C; Bavarian Center for Biomolecular Mass Spectrometry (BayBioMS), School of Life Sciences, Technical University of Munich, Freising, Germany., Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany., Kluck K; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Kirchner M; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Volckmar AL; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Center for Personalized Medicine (ZPM) Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg partner site, Heidelberg, Germany., Wirth M; Center for Translational Imaging (MoMAN), Ulm University, Ulm, Germany., Alhamdani MSS; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Hoheisel JD; Division of Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Löhr JM; Department of Clinical Science, Intervention and Technology (CLINTEC), Pancreas Cancer Research Lab, Karolinska Institute, Stockholm, Sweden., Seufferlein T; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Abaei A; Center for Translational Imaging (MoMAN), Ulm University, Ulm, Germany., Kemkemer R; School of Life Sciences, Reutlingen University, Reutlingen, Germany.; Department of Cellular Biophysics, Max Planck Institute for Medical Research, Heidelberg, Germany., Rad R; Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technische Universität München, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), TUM School of Medicine, Technische Universität München, Munich, Germany.; Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Technische Universität München, Munich, Germany.; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Budczies J; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Center for Personalized Medicine (ZPM) Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg partner site, Heidelberg, Germany., Mulaw MA; Unit for Single-Cell Genomics, Medical Faculty, Ulm University, Ulm, Germany., Hermann PC; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Haenle MM; Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE) , Ulm, Germany., Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, California., Gaulton KJ; Department of Pediatrics, University of California, San Diego, La Jolla, California., Steinestel K; Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Ulm, Germany., Stenzinger A; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.; Center for Personalized Medicine (ZPM) Heidelberg, Heidelberg, Germany.; German Cancer Consortium (DKTK), Heidelberg partner site, Heidelberg, Germany., Dusetti N; Cancer Research Center of Marseille (CRCM) , INSERM U1068, CNRS UMR 7258, Aix-Marseille University and Paoli-Calmettes Institute, Marseille, France., Perkhofer L; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.; Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany., Gout J; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany., Kleger A; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.; Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany.; Core Facility Organoids, Ulm University, Ulm, Germany.
Source: Cancer research [Cancer Res] 2026 Jul 15; Vol. 86 (14), pp. 3412-3435.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Roger+E%22">Roger E</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Mummey+HM%22">Mummey HM</searchLink>; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, California.<br /><searchLink fieldCode="AU" term="%22Zimmer+E%22">Zimmer E</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Srinivasan+D%22">Srinivasan D</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Härle+A%22">Härle A</searchLink>; Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Moubri+L%22">Moubri L</searchLink>; Cancer Research Center of Marseille (CRCM) , INSERM U1068, CNRS UMR 7258, Aix-Marseille University and Paoli-Calmettes Institute, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Michels+AK%22">Michels AK</searchLink>; 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