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A comparison of the effects of tirzepatide and dulaglutide on major kidney events in people with type 2 diabetes: pre-specified exploratory analyses of the SURPASS-CVOT trial.

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Title: A comparison of the effects of tirzepatide and dulaglutide on major kidney events in people with type 2 diabetes: pre-specified exploratory analyses of the SURPASS-CVOT trial.
Authors: Zoungas S; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Victorian Heart Institute, Monash University, Melbourne, VIC, Australia. Electronic address: sophia.zoungas@monash.edu., D'Alessio D; Duke University Medical Center, Durham, NC, USA., Pavo I; Eli Lilly and Company, Indianapolis, IN, USA., Bhatt DL; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buse JB; University of North Carolina, Chapel Hill, NC, USA., Prato SD; Interdisciplinary Research Center 'Health Science,' Sant'Anna School of Advanced Studies, Pisa, Italy., Kahn SE; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA., Lincoff AM; Department of Cardiovascular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA., McGuire DK; University of Texas Southwestern Medical Center and Parkland Health System, Dallas, TX, USA., Nauck MA; Diabetes, Endocrinology and Metabolism Section, Department of Medicine, St Josef-Hospital, Katholisches Klinikum Bochum, Ruhr University of Bochum, Bochum, Germany., Nissen SE; Cleveland Clinic Coordinating Center for Clinical Research (C5 Research) and Department of Medicine, Cleveland Clinic, Cleveland, OH, USA., Sattar N; School of Cardiovascular Medicine and Metabolic Health, University of Glasgow, Glasgow, UK., Zinman B; University of Toronto, Lunenfeld-Tanenbaum Research Institute and Mount Sinai Hospital, Toronto, ON, Canada., Ceriello A; IRCCS MultiMedica, Milan, Italy., Stechemesser L; Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria., Verhaegen A; Department of Endocrinology, Diabetes and Metabolism, Antwerp University Hospital, Edegem, and ZAS Jan Palfijn, Merksem, Belgium., Broder JC; Monash University Clinical Trials Centre, Monash University, Melbourne, VIC, Australia., Wolfe R; Monash University Clinical Trials Centre, Monash University, Melbourne, VIC, Australia., Miller D; Eli Lilly and Company, Indianapolis, IN, USA., Nishiyama H; Eli Lilly and Company, Indianapolis, IN, USA., Wang X; Eli Lilly and Company, Indianapolis, IN, USA., Weerakkody G; Eli Lilly and Company, Indianapolis, IN, USA., Wiese RJ; Eli Lilly and Company, Indianapolis, IN, USA., Nicholls SJ; Victorian Heart Institute, Monash University, Melbourne, VIC, Australia.
Source: The lancet. Diabetes & endocrinology [Lancet Diabetes Endocrinol] 2026 Jul; Vol. 14 (7), pp. 544-557. Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article; Randomized Controlled Trial; Comparative Study; Multicenter Study
Journal Info: Publisher: The Lancet, Diabetes & Endocrinology Country of Publication: England NLM ID: 101618821 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-8595 (Electronic) Linking ISSN: 22138587 NLM ISO Abbreviation: Lancet Diabetes Endocrinol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A comparison of the effects of tirzepatide and dulaglutide on major kidney events in people with type 2 diabetes: pre-specified exploratory analyses of the SURPASS-CVOT trial.
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  Data: <searchLink fieldCode="AU" term="%22Zoungas+S%22">Zoungas S</searchLink>; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Victorian Heart Institute, Monash University, Melbourne, VIC, Australia. Electronic address: sophia.zoungas@monash.edu.<br /><searchLink fieldCode="AU" term="%22D'Alessio+D%22">D'Alessio D</searchLink>; Duke University Medical Center, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pavo+I%22">Pavo I</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Bhatt+DL%22">Bhatt DL</searchLink>; Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Buse+JB%22">Buse JB</searchLink>; University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Prato+SD%22">Prato SD</searchLink>; Interdisciplinary Research Center 'Health Science,' Sant'Anna School of Advanced Studies, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Kahn+SE%22">Kahn SE</searchLink>; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Lincoff+AM%22">Lincoff AM</searchLink>; Department of Cardiovascular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22McGuire+DK%22">McGuire DK</searchLink>; University of Texas Southwestern Medical Center and Parkland Health System, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nauck+MA%22">Nauck MA</searchLink>; Diabetes, Endocrinology and Metabolism Section, Department of Medicine, St Josef-Hospital, Katholisches Klinikum Bochum, Ruhr University of Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Nissen+SE%22">Nissen SE</searchLink>; Cleveland Clinic Coordinating Center for Clinical Research (C5 Research) and Department of Medicine, Cleveland Clinic, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Sattar+N%22">Sattar N</searchLink>; School of Cardiovascular Medicine and Metabolic Health, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Zinman+B%22">Zinman B</searchLink>; University of Toronto, Lunenfeld-Tanenbaum Research Institute and Mount Sinai Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ceriello+A%22">Ceriello A</searchLink>; IRCCS MultiMedica, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Stechemesser+L%22">Stechemesser L</searchLink>; Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria.<br /><searchLink fieldCode="AU" term="%22Verhaegen+A%22">Verhaegen A</searchLink>; Department of Endocrinology, Diabetes and Metabolism, Antwerp University Hospital, Edegem, and ZAS Jan Palfijn, Merksem, Belgium.<br /><searchLink fieldCode="AU" term="%22Broder+JC%22">Broder JC</searchLink>; Monash University Clinical Trials Centre, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Wolfe+R%22">Wolfe R</searchLink>; Monash University Clinical Trials Centre, Monash University, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Miller+D%22">Miller D</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nishiyama+H%22">Nishiyama H</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Weerakkody+G%22">Weerakkody G</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Wiese+RJ%22">Wiese RJ</searchLink>; Eli Lilly and Company, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nicholls+SJ%22">Nicholls SJ</searchLink>; Victorian Heart Institute, Monash University, Melbourne, VIC, Australia.
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  Data: <searchLink fieldCode="JN" term="%22101618821%22">The lancet. Diabetes & endocrinology</searchLink> [Lancet Diabetes Endocrinol] 2026 Jul; Vol. 14 (7), pp. 544-557. <i>Date of Electronic Publication: </i>2026 May 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22The+Lancet%2C+Diabetes+%26+Endocrinology%22">The Lancet, Diabetes & Endocrinology </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101618821 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-8595 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222138587%22">22138587 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Diabetes Endocrinol <i>Subsets: </i>MEDLINE
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