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Chitosan-shielded stem cell exosomes as a tight-junction-modulating bio-shuttle for enhanced transdermal delivery and skin rejuvenation.

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Title: Chitosan-shielded stem cell exosomes as a tight-junction-modulating bio-shuttle for enhanced transdermal delivery and skin rejuvenation.
Authors: Oh H; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea., Oh SM; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea., Lee Y; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea., Choi Y; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea., Son P; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea., Kwon JH; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea., Park TE; School of Chemical Engineering, College of Engineering, Pusan National University, Busan, 46241, Republic of Korea., Kim KS; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea., Ki YW; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea., Cheon GJ; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute & Institute on Aging, Seoul National University, Seoul, Republic of Korea., Choi WI; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea. Electronic address: choi830509@kicet.re.kr., Hwang DW; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea. Electronic address: dwhwang@therabest.co.kr.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Jun; Vol. 369, pp. 152484. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
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  Data: Chitosan-shielded stem cell exosomes as a tight-junction-modulating bio-shuttle for enhanced transdermal delivery and skin rejuvenation.
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  Data: <searchLink fieldCode="AU" term="%22Oh+H%22">Oh H</searchLink>; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+SM%22">Oh SM</searchLink>; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+Y%22">Choi Y</searchLink>; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Son+P%22">Son P</searchLink>; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea; Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwon+JH%22">Kwon JH</searchLink>; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+TE%22">Park TE</searchLink>; School of Chemical Engineering, College of Engineering, Pusan National University, Busan, 46241, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+KS%22">Kim KS</searchLink>; Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ki+YW%22">Ki YW</searchLink>; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cheon+GJ%22">Cheon GJ</searchLink>; Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institute & Institute on Aging, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+WI%22">Choi WI</searchLink>; Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, Cheongju, 28160, Republic of Korea. Electronic address: choi830509@kicet.re.kr.<br /><searchLink fieldCode="AU" term="%22Hwang+DW%22">Hwang DW</searchLink>; Research and Development Center, THERABEST, Co., Ltd., Seoul, Republic of Korea. Electronic address: dwhwang@therabest.co.kr.
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  Data: <searchLink fieldCode="JN" term="%227909578%22">International journal of biological macromolecules</searchLink> [Int J Biol Macromol] 2026 Jun; Vol. 369, pp. 152484. <i>Date of Electronic Publication: </i>2026 May 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>7909578 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0003 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201418130%22">01418130 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Macromol <i>Subsets: </i>MEDLINE
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              Text: 2026 Jun
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