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Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance.

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Title: Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance.
Authors: Zhao W; Department of Mathematics and the NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA; Diabetes Center, University of California Irvine, Irvine, CA, USA., Jiao X; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Du K; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Sun Q; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Duan J; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA., Cao Y; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Shen X; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Said Z; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Karri SS; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA., Ellsworth P; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Hu W; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA., Sargsyan A; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA., Astapova I; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Kim SY; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gonzalez J; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Higgins-Chen AT; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Perry RJ; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA., Seki E; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Herman MA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Andersen B; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA., Nie Q; Department of Mathematics and the NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA; Diabetes Center, University of California Irvine, Irvine, CA, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. Electronic address: qnie@uci.edu., Yang Q; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA. Electronic address: qin.yang@uci.edu.
Source: Metabolism: clinical and experimental [Metabolism] 2026 Aug; Vol. 181, pp. 156630. Date of Electronic Publication: 2026 May 09.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell and spatial omics in liver identify cell-cell communication regulators in aging and insulin resistance.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Mathematics and the NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA; Diabetes Center, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Jiao+X%22">Jiao X</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Du+K%22">Du K</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Q%22">Sun Q</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Y%22">Cao Y</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Said+Z%22">Said Z</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Karri+SS%22">Karri SS</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ellsworth+P%22">Ellsworth P</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+W%22">Hu W</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sargsyan+A%22">Sargsyan A</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Astapova+I%22">Astapova I</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kim+SY%22">Kim SY</searchLink>; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+J%22">Gonzalez J</searchLink>; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Higgins-Chen+AT%22">Higgins-Chen AT</searchLink>; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Perry+RJ%22">Perry RJ</searchLink>; Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Seki+E%22">Seki E</searchLink>; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Herman+MA%22">Herman MA</searchLink>; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Andersen+B%22">Andersen B</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nie+Q%22">Nie Q</searchLink>; Department of Mathematics and the NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA; Diabetes Center, University of California Irvine, Irvine, CA, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA. Electronic address: qnie@uci.edu.<br /><searchLink fieldCode="AU" term="%22Yang+Q%22">Yang Q</searchLink>; Diabetes Center, University of California Irvine, Irvine, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Irvine, Irvine, CA, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA. Electronic address: qin.yang@uci.edu.
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