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Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report.

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Title: Continuous Subcutaneous Ketamine Infusion May Induce Tacrolimus and Sirolimus Clearance: A Case Report.
Authors: Stojanova J; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia., Murnion B; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia., Burrows F; Pharmacy Department, St. Vincent's Hospital, Sydney, Australia., Carlos L; Pharmacy Department, St. Vincent's Hospital, Sydney, Australia., Mizuno T; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Nadai T; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Irie K; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA., Helsby N; Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Muthiah K; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.; Department of Cardiology, St Vincent's Hospital Sydney, Sydney, Australia., Day R; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
Source: Pharmacotherapy [Pharmacotherapy] 2026 Jun; Vol. 46 (6), pp. e70150.
Publication Type: Case Reports; Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8111305 Publication Model: Print Cited Medium: Internet ISSN: 1875-9114 (Electronic) Linking ISSN: 02770008 NLM ISO Abbreviation: Pharmacotherapy Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Stojanova+J%22">Stojanova J</searchLink>; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Murnion+B%22">Murnion B</searchLink>; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Burrows+F%22">Burrows F</searchLink>; Pharmacy Department, St. Vincent's Hospital, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Carlos+L%22">Carlos L</searchLink>; Pharmacy Department, St. Vincent's Hospital, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Mizuno+T%22">Mizuno T</searchLink>; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Nadai+T%22">Nadai T</searchLink>; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Irie+K%22">Irie K</searchLink>; Division of Translational and Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Helsby+N%22">Helsby N</searchLink>; Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Muthiah+K%22">Muthiah K</searchLink>; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.; Department of Cardiology, St Vincent's Hospital Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Day+R%22">Day R</searchLink>; Department of Clinical Pharmacology and Toxicology, St Vincent's Hospital, Sydney, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
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              Text: 2026 Jun
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