View in EDS

All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.

Saved in:
Bibliographic Details
Title: All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.
Authors: Li CF; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org., Wei Y; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee HH; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang WC; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan., Xiong Y; Proteomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tang Y; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yang R; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The AHMC Dermatology and Research Center, Arcadia, CA, USA., Yao J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang H; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang X; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu M; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Park J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fu J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang YN; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bai LY; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan., Wang SC; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan., Chou CW; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Division of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Ling J; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chu YY; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Xun Z; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang H; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yao W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Yu D; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Chiao PJ; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA., Ying H; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. HYing@mdanderson.org.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. HYing@mdanderson.org., Hung MC; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mhung@cmu.edu.tw.; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.
Source: Nature communications [Nat Commun] 2026 May 11; Vol. 17 (1). Date of Electronic Publication: 2026 May 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42115161
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Li+CF%22">Li CF</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. cli14@mdanderson.org.<br /><searchLink fieldCode="AU" term="%22Wei+Y%22">Wei Y</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lee+HH%22">Lee HH</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chang+WC%22">Chang WC</searchLink>; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Proteomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The AHMC Dermatology and Research Center, Arcadia, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yao+J%22">Yao J</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Park+J%22">Park J</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fu+J%22">Fu J</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+YN%22">Wang YN</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bai+LY%22">Bai LY</searchLink>; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+SC%22">Wang SC</searchLink>; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan.; Department of Biotechnology, Asia University, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+CW%22">Chou CW</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan.; Division of Hematology/Medical Oncology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ling+J%22">Ling J</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chu+YY%22">Chu YY</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xun+Z%22">Xun Z</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Maitra+A%22">Maitra A</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yao+W%22">Yao W</searchLink>; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yu+D%22">Yu D</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Chiao+PJ%22">Chiao PJ</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ying+H%22">Ying H</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. HYing@mdanderson.org.; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. HYing@mdanderson.org.<br /><searchLink fieldCode="AU" term="%22Hung+MC%22">Hung MC</searchLink>; Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. mhung@cmu.edu.tw.; Center for Molecular Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Division of Hematology and Oncology, Department of Internal Medicine, China Medical University Hospital, and China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Graduate Institute of Biomedical Sciences, College of Medicine, and Institute of Biochemistry and Molecular Biology, College of Life Sciences, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan. mhung@cmu.edu.tw.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 May 11; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 May 11.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42115161
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-72271-5
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Li CF
      – PersonEntity:
          Name:
            NameFull: Wei Y
      – PersonEntity:
          Name:
            NameFull: Lee HH
      – PersonEntity:
          Name:
            NameFull: Chang WC
      – PersonEntity:
          Name:
            NameFull: Xiong Y
      – PersonEntity:
          Name:
            NameFull: Tang Y
      – PersonEntity:
          Name:
            NameFull: Yang R
      – PersonEntity:
          Name:
            NameFull: Yao J
      – PersonEntity:
          Name:
            NameFull: Wang H
      – PersonEntity:
          Name:
            NameFull: Wang X
      – PersonEntity:
          Name:
            NameFull: Liu M
      – PersonEntity:
          Name:
            NameFull: Park J
      – PersonEntity:
          Name:
            NameFull: Fu J
      – PersonEntity:
          Name:
            NameFull: Wang YN
      – PersonEntity:
          Name:
            NameFull: Bai LY
      – PersonEntity:
          Name:
            NameFull: Wang SC
      – PersonEntity:
          Name:
            NameFull: Chou CW
      – PersonEntity:
          Name:
            NameFull: Ling J
      – PersonEntity:
          Name:
            NameFull: Chu YY
      – PersonEntity:
          Name:
            NameFull: Xun Z
      – PersonEntity:
          Name:
            NameFull: Liang H
      – PersonEntity:
          Name:
            NameFull: Maitra A
      – PersonEntity:
          Name:
            NameFull: Yao W
      – PersonEntity:
          Name:
            NameFull: Yu D
      – PersonEntity:
          Name:
            NameFull: Chiao PJ
      – PersonEntity:
          Name:
            NameFull: Ying H
      – PersonEntity:
          Name:
            NameFull: Hung MC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 05
              Text: 2026 May 11
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1